Every lot is tried & tested in a relevant biological assay.
- Stórustovu, S.I. and Ebert, B. (2006) J. Pharmacol. Exp. Ther. 316, 1351.
- Alomone Labs Isoguvacine hydrochloride activates GABA(A) receptors expressed in Xenopus oocytes.Time course of GABA(A) α1/β2 currents activation by 0.1 µM and 1 µM Isoguvacine hydrochloride (#I-185) at a holding potential of -60 mV.
Isoguvacine hydrochloride is a specific and potent agonist of GABA(A) receptors with an EC50 value of 3.7–17.3 µM, depending on the subunit composition1. It is a semirigid analogue of trans-4-aminocrotonic acid with limited conformational flexibility and is less potent than GABA1,2.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system, and play an important role in inhibiting cell excitation in the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs3,4.
Isoguvacine hydrochloride (#I-185) is a highly pure, synthetic, and biologically active compound.
- Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001)
- Anti-GABA(A) α2 Receptor Antibody (#AGA-002)
- Anti-GABA(A) α3 Receptor (extracellular) Antibody (#AGA-003)
- Anti-GABA(A) α6 Receptor (extracellular) Antibody (#AGA-004)
- Waglerin-1 (#STW-001)
- α-Asarone (#A-260)
- 2’MeO6MF (#M-245)
- (+)-Bicuculline (#B-135)
- α-Bungarotoxin (#B-100)
- Flumazenil (#F-145)
- GABA(A) Receptor Antibody Explorer Kit (#AK-229)
- GABA(A) Receptor Modulator Explorer Kit (#EK-360)