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Kainic acid monohydrate

Kainate
A Selective Agonist of Kainate Receptors and a Partial Agonist of AMPA Receptors
Cat #: K-200
Alternative Name Kainate
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 231.25
    Purity: >99%
    Effective concentration 0.1-10 µM.
    Structure
    Chemical name (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid;hydrate.
    Molecular formula C10H15NO4 · H2O
    CAS No.: 58002-62-3.
    PubChem CID 11954253
    Activity Kainic acid, a cyclic analogue of glutamic acid, is a selective agonist of the kainate receptors (EC50 = 0.6 µM – 7.4 µM, depending on subtype) 1,2, and a partial agonist at AMPA receptors (EC50 = 31 µM – 170 µM, depending on subtype) 1,3. Kainic acid has neuro-excitotoxic and epileptogenic activity in vivo4,5.
    References-Activity
    1. Donevan, S.D. et al. (1998) J. Pharmacol. Exp. Ther. 285, 539.
    2. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.
    3. Armstrong, N. and Gouaux, E. (2000) Neuron 28, 165.
    4. Kim, S. et al. (2017) Exp. Neurobiol. 26, 266.
    5. Foster, J.A. et al. (2003) J. Chem. Neuroanat. 26, 65.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
    Solubility Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.
    Storage of solutions Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.
    Our bioassay
    • Alomone Labs Kainic acid monohydrate activates kainate receptors expressed in Xenopus oocytes.
      Alomone Labs Kainic acid monohydrate activates kainate receptors expressed in Xenopus oocytes.
      A representative time course of GluK1 (GluR5) current, activated by a transient application of 1 µM Kainic acid monohydrate (#K-200) at a holding potential of -80 mV.
    References - Scientific background
    1. Kim, S. et al. (2017) Exp. Neurobiol. 26, 266.
    2. Wang, Y. et al. (2008) Autophagy 4, 214.
    3. Foster, J.A. et al. (2003) J. Chem. Neuroanat. 26, 65.
    4. Orav, E. et al. (2017) eNeuro 4, e0048.
    Scientific background

    Kainic acid is an analog of the excitotoxic neurotransmitter glutamate used as a selective agonist of Kainate receptors1,2.

    Studies show that treatment with Kainic acid may induce seizures leading to neuronal death and biochemical changes similar to those seen in human patients with temporal lobe epilepsy1. Kainic acid may induce apoptotic death of rat striatal neurons in an autophagic mechanism2. Several studies of rat model show progressive death of nigral neurons following unilateral injection of Kainic acid in the striatum3.

    Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability and synaptogenesis4.

    Target Kainate receptors, AMPA receptors
    Last update: 23/08/2020

    Kainic acid monohydrate (#K-200) is a highly pure, synthetic, and biologically active compound. 

    For research purposes only, not for human use
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