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Certificate of Analysis

  • Bioassay Tested

KV Channel Blockers for Pain Research Explorer Kit

A Screening Package of KV Channel Blockers for Pain Research Economically Priced

Cat #: EK-380
Size: 9 Vials
Form: Lyophilized

β-Dendrotoxin Cat #: D-360

Size: 35 µg MW: ~7000 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).
Effective concentration
10-500 nM.
Activity
β-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K+ channels (KV1.1, KV1.2).
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Dendrotoxin-I Cat #: D-390

Size: 0.14 mg MW: 7149 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).
Effective concentration
10-100 nM.
Activity
Dendrotoxin-I is a highly selective blocker of voltage-gated Kchannels (KV1.1 and KV1.2), as well as heteromultimeric channels containing these, with other KV1 isoforms1. The inhibition effect is higher in Xenopus oocytes compared to mammalian cells2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up one week at 4°C or three months at -20°C.

Dendrotoxin-K Cat #: D-400

Size: 10 µg MW: 6560 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).
Effective concentration
100 nM
Activity
Dendrotoxin-K is a highly selective blocker of voltage-gated Kchannels (KV1.1 and KV1.2).
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer (pH 7.5). Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
One week at 4°C or six months at -20°C.

Heteropodatoxin-2 Cat #: STH-340

Size: 0.1 mg MW: 3413 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
100-500 nM.
Activity
Heteropodatoxin-2 is an inhibitor of voltage-gated Kchannels of the KV4 family. Inhibition of KV4.3 and KV4.2 is strongly voltage-dependent, while inhibition of KV4.1 shows less voltage-dependence. Lacks affinity for KV1.4, KV2.1 and KV3.41,2. Also blocks Ca2+ channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

Hongotoxin-1 Cat #: STH-400

Size: 0.1 mg MW: 4220 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
0.1-0.2 pM.
Activity
Hongotoxin-1 is a potent selective inhibitor of KV1.1, KV1.2 and KV1.3 voltage-gated K+ channels and a weak inhibitor of KV1.6 K+ channel. Hongotoxin does not block KV1.4 nor KV1.5 currents1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Linopirdine dihydrochloride Cat #: L-156

Size: 5 mg Source: Synthetic MW: 464.39 Purity: >98%
Effective concentration
0.1-300 µM.
Activity
Linopirdine blocks KCNQ channels with an IC50 of 2.4 μM for KV7.2/3 heteromers1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

MCD peptide Cat #: STM-250

Size: 0.5 mg MW: 2588 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10 nM - 1 μM.
Activity
MCD peptide inhibits KV1.1 and KV1.2 channels1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or six months at -20°C.

Phrixotoxin-1 Cat #: STP-700

Size: 50 µg MW: 3549 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-100 nM.
Activity
Phrixotoxin-1 specifically and reversibly blocks KV4.2 and KV4.3 channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

XE991 dihydrochloride Cat #: X-101

Size: 5 mg Source: Synthetic MW: 449.37 Purity: >98%
Effective concentration
0.1-300 µM.
Activity
XE991 blocks KCNQ channels with IC50 of 0.5-10 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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