Every lot is tried & tested in a relevant biological assay.
- Alomone Labs mouse, rat Galanin-Biotin activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.Dose response of normalized activation of Galanin 2 receptor-mediated Ca2+ mobilization, evoked by mouse, rat Galanin-Biotin (#GPG-100-B). Ca2+ response was detected by measuring aequorin-derived fluorescence following application of mouse, rat Galanin-Biotin at different concentrations. The EC50 measured is 4.42 nM.
Galanin is a peptide hormone that acts as a non-selective and potent galanin receptor agonist. Galanin is a C-terminally amidated 29-residue peptide (30 in humans). It was first isolated from porcine intestine1,2.
Galanin is widely distributed throughout the central and peripheral nervous systems and its biological activity includes contraction or relaxation of gut smooth muscles, inhibition of insulin and somatostatin release, and modulation of hormone secretion from the pituitary and adrenal gland. It is believed that galanin plays an important role as a neuromodulator of endocrine secretion and synaptic transmission1.
Galanin receptors belong to the family of G-protein coupled receptors and consist of three subtypes: GalR1, GalR2, and GalR3. Additional studies show that galanin and its receptors are involved in the transmission and modulation of nociception2.
mouse, rat Galanin-Biotin (#GPG-100-B) is a highly pure, synthetic, and biologically active conjugated peptide.