Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Volkmann, R.A. et al. (2016) PLoS ONE 11, e0148129.
- Alomone Labs MPX-004 inhibits NMDA receptor channels expressed in Xenopus oocytes.A. Time course of NR1/NR2A currents, elicited by transient stimulations with 200 µM glutamate and 200 µM glycine every 100 sec, while membrane potential was held at -80 mV. 100 nM MPX-004 (#M-280), applied for 7 min (bar), significantly inhibits current amplitude. B. Superimposed current traces from the recording shown in A, upon application of control and of 100 nM MPX-004 (as indicated).
- Volkmann, R.A. et al. (2016) PLoS ONE 11, e0148129.
- Cercato, M.C. et al. (2017) Front. Behav. Neurosci. 10, 242.
MPX-004 is a synthetic compound that acts as a potent and selective GluN2A-containing NMDA receptor antagonist with an IC50 value of 79 nM in HEK cells1.
MPX-004 is a pyrazine-containing antagonist with optimal halogen substituents on the phenylsulfonamide aryl ring. It is used as a pharmacological tool for studying the physiology of NMDA receptors containing the GluN2A subunit1.
NMDA receptors are heterotetramers composed by 2 GluN1 obligatory subunits and 2 GluN2 (A-D) or GluN3 (A-B) regulatory subunits. GluN2A is the most abundant subunit in the mammalian CNS. Physiological and genetic evidence show that GluN2A-containing receptors are involved in autism, schizophrenia, childhood epilepsy and neurodevelopmental disorders such as Rett Syndrome1,2.
MPX-004 (#M-280) is a highly pure, synthetic, and biologically active compound.
Applications
Citations
- Mouse primary hippocampal neurons.
Chan, K. et al. (2020) Nat. Commun. 11, 1403.
Specifications
Scientific Background
Related Products
- Anti-NMDAR2A (GluN2A) (extracellular) Antibody (#AGC-002)
- Anti-NMDAR2A (GluN2A) (extracellular)-ATTO Fluor-488 Antibody (#AGC-002-AG)
- NMDA Receptor Antibody Explorer Kit (#AK-214)
- NMDA Receptor Antagonist Explorer Kit (#EK-350)
- TCN 201 (#T-190)
- TCN 213 (#T-215)
- CNS-1102 (#C-305)
- DL-AP5 (#D-140)
- D-AP5 (#D-145)
- QNZ 46 (#Q-270)
- CIQ (#C-275)
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us