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NAX-5055

Gal-B2

An Agonist of GalR1 and GalR2 Galanin Receptors

Cat #: N-360
Alternative Name Gal-B2
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic
    MW: 2112.6 Da
    Purity: >98% (HPLC)
    Effective concentration 1-100 nM.
    Sequence (Sar)WTLNSAGYLLGPKKK(pal)K-NH2.
    Modifications N-terminal glycine is substituted with sarcosine. Lys at position 16 is palmitoylated. C-terminal amidation.
    Structure
    Molecular formula C104H174N24O22.
    Activity NAX-5055, a systemically active analogue of the endogenous neuropeptide galanin, is a high affinity galanin receptors ligand (Ki=3.5 nM and 51.5 nM for GalR1 and GalR2, respectively), shown to prevent seizures in mouse epilepsy model in vivo1,2.
    References-Activity
    1. Bulaj, G. et al. (2008) J. Med. Chem. 51, 8038.
    2. White, H.S. et al. (2009) Neurotherapeutics 6, 372.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
    Storage of solutions Up to three months at -20°C.
    Our bioassay
    • Alomone Labs NAX-5055 activates GalR2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt-Aequorin cells.
      Alomone Labs NAX-5055 activates GalR2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt-Aequorin cells.
      Dose response of normalized NAX-5055 (#N-360) activation of GalR2 receptor-mediated Ca2+ mobilization, measured as aequorin-derived fluorescence following NAX-5055 application (EC50 = 6.12 nM).
    References - Scientific background
    1. Bulaj, G. et al. (2008) J. Med. Chem. 51, 8038.
    2. White, H.S. et al. (2009) Neurotherapeutics 6, 372.
    3. Flynn, S.P. and White, H.S. (2015) Neuropeptides 50, 35.
    4. Zhang, M.L. et al. (2017) Sci. Rep. 7, 45930.
    Scientific background

    NAX-5055 is an active analog of the endogenous neuropeptide galanin that acts as a galanin receptor 1 (GalR1) and galanin receptor 2 (GalR2) agonist. NAX-5055 demonstrates high affinity for the receptors and was shown to prevent seizures in mouse model of epilepsy following intraperitoneal administration1.

    NAX-5055 is a systemically-active, metabolically stable galanin analog that can penetrate the blood-brain-barrier and displays a potent anticonvulsant activity2,3.

    Galanin is widely expressed throughout the central and peripheral nervous systems. Galanin receptors belong to the family of G-protein coupled receptors. Studies show that galanin and its receptors are involved in the transmission and modulation of nociception in the central nervous system, at spinal cord levels and in the brain4.

    Target Galanin Receptors
    Lyophilized Powder
    Last update: 06/11/2022

    NAX-5055 (#N-360) is a highly pure, synthetic, and biologically active modified peptide.

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    For research purposes only, not for human use
    Shipping and Ordering information

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