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PD-160725 2-hydroxyethanesulfonate

PD-160725 isethionate salt
AMPA Receptor Antagonist
Cat #: P-280
Alternative Name PD-160725 isethionate salt
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 444.46
    Purity: >98%
    Effective concentration 0.1-100 µM.
    Structure
    Chemical name 2-hydroxyethanesulfonic acid;6-methyl-7-nitro-5-(piperidin-1-ylmethyl)-1,4-dihydroquinoxaline-2,3-dione.
    Molecular formula C17H24N4O8S.
    CAS No.: 1262769-92-5.
    PubChem CID 71312022
    Activity PD-160725 2-hydroxyethanesulfonate is an AMPA receptor antagonist.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 20 mM in H2O (slowly, clear yellow solution). Centrifuge all products before reconstitution (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.
    Our bioassay
    • Alomone Labs PD-160725 2-hydroxyethanesulfonate inhibits GluA1 channels expressed in Xenopus oocytes. 
      Alomone Labs PD-160725 2-hydroxyethanesulfonate inhibits GluA1 channels expressed in Xenopus oocytes. 
      Time course of GluA1 currents, activated by a continuous application (top dotted line) of 1 µM glutamate, and reversibly inhibited by 2 µM and 10 µM PD-160725 2-hydroxyethanesulfonate (#P-280), as indicated (bars), at a holding potential of -80 mV.
    References - Scientific background
    1. Niu, L. (2015) Acta. Pharm. Sin. B. 5, 500.
    2. Guntupalli, S. et al. (2016) Neural. Plast. 2016, 3204519.
    Scientific background

    PD-160725 2-hydroxyethanesulfonate is an AMPA receptor antagonist. Antagonists of AMPA receptors are good candidates for potential treatment of several neurological disorders including epilepsy, stroke and amyotrophic lateral sclerosis1,2.

    The ionotropic glutamate AMPA receptors (AMPARs) are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane2.

    Target AMPA receptors
    Lyophilized Powder
    Last update: 23/08/2020

    PD-160725 2-hydroxyethanesulfonate (#P-280) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
    Shipping and Ordering information

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