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PD-161989 2-hydroxyethanesulfonate

PD-161989 2-hydroxyethanesulfonic acid salt , PD-161989 isethionate salt

An Antagonist of AMPA Receptors

Cat #: P-285
Alternative Name PD-161989 2-hydroxyethanesulfonic acid salt , PD-161989 isethionate salt
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 430.43
    Purity: >99%
    Effective concentration 0.1-100 µM.
    Structure
    Chemical name 2-hydroxyethanesulfonic acid;6-methyl-7-nitro-5-(pyrrolidin-1-ylmethyl)-1,4-dihydroquinoxaline-2,3-dione.
    Molecular formula C16H22N4O8S.
    CAS No.: 1262770-05-7
    PubChem CID 71311958
    Activity PD-161989 2-hydroxyethanesulfonate is an AMPA receptor antagonist.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 20 mM in H2O or DMSO (slowly, clear yellow solution). Centrifuge all products before reconstitution (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.
    Our bioassay
    • Alomone Labs PD-161989 2-hydroxyethanesulfonate inhibits GluA1 channels expressed in Xenopus oocytes. 
      Alomone Labs PD-161989 2-hydroxyethanesulfonate inhibits GluA1 channels expressed in Xenopus oocytes. 
      Time course of GluA1 current activation by application (top dotted line) of 1 µM glutamate, and its reversibe inhibition by 2 µM and 10 µM PD-161989 2-hydroxyethanesulfonate (#P-285), as indicated (bars), at a holding potential of -80 mV.
    References - Scientific background
    1. Armstrong, N. et al. (1998) Nature 395, 913.
    Scientific background

    Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). AMPA receptors are ionotropic glutamate channels, play a key role in the development and function of the nervous system and are essential in memory and learning1.

    PD-161989 2-hydroxyethanesulfonate is a synthetic, potent and selective antagonist of AMPA glutamate receptors. It has an effective concentration of 0.1-100 µM.

    Target AMPA receptors
    Last update: 11/04/2021

    PD-161989 2-hydroxyethanesulfonate (#P-285) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information