Every lot is tried & tested in a relevant biological assay.
- Jones, H.M. et al. (2016) Clin. Pharmacokinet. 55, 875.
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Alomone Labs PF-05241328 blocks NaV1.7 channels expressed in Xenopus oocytes.A. Representative time course of PF-05241328 (#P-345) inhibition of NaV1.7 channel current. Membrane potential was held at -100 mV. Current was elicited by a 100 ms voltage step to 0 mV every 10 sec and inhibited by 10 µM and 50 µM PF-05241328 application (horizontal bars). B. Superimposed traces of NaV1.7 current upon application of control and of 10 µM and 50 µM PF-05241358, as indicated.
PF-05241328 a potent and selective blocker of NaV1.7 channels with IC50 value of 31 nM1. PF-05089771 is being used to explore the NaV1.7 channel blockade for the treatment of acute or chronic pain conditions1,2.
NaV1.7 channel plays an important role in the human pain signaling pathway and it is an important therapeutic target for treatment of chronic pain.
PF-05241328 (#P-345) is a highly pure, synthetic, and biologically active compound.