Pyrrolopyrimidine 48

Pyrrolopyrimidine 14, BDBM14191, N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4-(2-methoxyethyl)piperazin-1-amine
A Blocker of NaV1.7 and NaV1.5 Channel
    Cat #: P-275
    Alternative Name Pyrrolopyrimidine 14, BDBM14191, N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4-(2-methoxyethyl)piperazin-1-amine
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 385.46
    Purity: >99% (HPLC)
    Effective concentration 50 nM - 20 µM.
      • Pyrrolopyrimidine 48
    Chemical name 7-benzyl-4-(1-pyridin-2-ylpiperidin-4-yl)oxypyrrolo[2,3-d]pyrimidine.
    Molecular formula C23H23N5O.
    PubChem CID 73755149
    Activity Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel with an IC50 value of 0.11 µM. It also blocks NaV1.5 channel with an IC50 of 0.16 µM1.
      • Chakka, N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 2052.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Pyrrolopyrimidine 48
        Alomone Labs Pyrrolopyrimidine 48 blocks NaV1.7 channels expressed in Xenopus oocytes.
        A. Time course of NaV1.7 current amplitude and inhibition by 1 and 10 µM Pyrrolopyrimidine 48 (#P-275). Currents were elicited by application of a 20 ms voltage step to 0 mV (H.P= -100 mV), every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 1 and 10 µM Pyrrolopyrimidine 48, as indicated.
    References - Scientific background
    • 1. Chakka, N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 2052.
      • Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel developed using structure-activity relationship of the channel. It blocks human NaV1.7 with an IC50 value of 0.11 µM and NaV1.5 channel with an IC50 of 0.16 µM. It exhibits good selectivity over hERG K+ channel1.

    Target NaV1.7, NaV1.5 channels
    Last update: 20/11/2019

    Pyrrolopyrimidine 48 (#P-275) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use