Every lot is tried & tested in a relevant biological assay.
- Alomone Labs Ro 25-6981 maleate inhibits NMDA receptor channels expressed in Xenopus oocytes.A. Representative time course of NR1/NR2A currents, elicited by transient stimulations with 100 µM glutamate + 100 µM glycine every 50 sec, while membrane potential was held at -80 mV. 3 min application (indicated by bar) of 100 µM Ro 25-6981 maleate (#R-180) significantly inhibits current amplitude. B. Superimposed current traces from the recording shown in A, upon application of control and of 100 µM Ro 25-6981 maleate (as indicated).
Ro 25-6981 maleate is a highly potent and selective antagonist of GluN2B-containing NMDA receptors. The compound is an activity dependent antagonist of the receptor and demonstrates 5000 times fold selectivity for NR2B-containing receptors over NR2A-containing receptors1. Ro 25-6981 demonstrates an IC50 value of 0.009 µM towards NR2B-containing receptors and an IC50 of 52 µM towards NR2A-containing receptors1.
Ro 25-6981 protects cultured cortical neurons against glutamate toxicity and has anti-depressant and anti-inflammatory effects. It can suppress ischemic brain injury by regulating autophagy-related proteins during ischemia1,2.
NMDA receptors are composed of NR1 including eight different splice variants and NR2A-D. They are activated by the co-agonists glutamate and glycine1,2.
Ro 25-6981 maleate (#R-180) is a highly pure, synthetic, and biologically active compound.
- 7-Chlorokynurenic acid (#C-285)
- CGP-37849 (#C-325)
- Clobenpropit dihydrobromide (#C-345)
- CNS-1102 (#C-305)
- DL-AP5 (#D-140)
- DL-AP7 (#D-200)
- DQP-1105 (#D-210)
- L-689,560 (#L-225)
- MPX-004 (#M-280)
- QNZ 46 (#Q-270)
- Ro 8-4304 hydrochloride (#R-165)
- Eliprodil (#E-155)
- TCN 201 (#T-190)
- TCN 213 (#T-215)
- ZD 9379 (#Z-120)