Every lot is tried & tested in a relevant biological assay.
- Alomone Labs SNAP 37889 inhibits GalR2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt-Aequorin cells.Dose-response of normalized SNAP 37889 (#S-210) inhibition of the galanin-evoked, GalR2 receptor-mediated Ca2+ mobilization, measured as aequorin-derived fluorescence following galanin application (IC50 = 7.57 µM).
SNAP 37889 is a potent and selective Galanin 3 receptor (GalR3) antagonist. The compound exists as E- and Z-isomers that interconvert quickly in solution at room temperature1,2.
Studies conducted in animals show that acute administration of SNAP 37889 enhances rat social interaction, reduces guinea pig vocalizations after maternal separation, and attenuates stress-induced hyperthermia in mice1.
Galanin is a widely distributed neuropeptide that regulates various endocrine, pain and cognitive functions, including learning and memory in the central nervous system (CNS). It activates one of three receptors belonging to the GPCR superfamily: GalR1, GalR2 and GalR3. GAL3 receptors are involved in anxiety, depression, and drug-seeking behavior1,2.
SNAP 37889 (#S-210) is a highly pure, synthetic, and biologically active compound.