Every lot is tried & tested in a relevant biological assay.
- Alomone Labs Stromatoxin-1 inhibits KV2.1 channels heterologously expressed in Xenopus oocytes.Left: Time course of KV2.1 current amplitude before and during application of 100 nM Stromatoxin-1 (#STS-350). The periods of Stromatoxin-1 perfusion is indicated by the horizontal bar.
Right: Stromatoxin-1 dose-dependent inhibition of KV2.1 current amplitude.
Stromatoxin-1 is a 34 amino acid peptidyl toxin originally isolated from Stromatopelma calceatum tarantula1. Structurally, Stromatoxin-1 belongs to the scaffold of structural inhibitor cysteine knot peptide family, which were shown to function as gating modifiers2.
Stromatoxin-1 selectively inhibits KV2.1, KV2.1/9.3, and KV4.2 channel currents (IC50 of 12.7 nM, 7.2 nM and 1.2 nM respectively), and is the first high-affinity voltage gating modifier inhibitor of the KV2.2 channel subtype (IC50, 21.4 nM) to be discovered1.
Stromatoxin-1 (#STS-350) is a highly pure, synthetic, and biologically active peptide toxin.
- Nishijima, Y. et al. (2017) Circ. Res. 120, 658.
- Regnier, G. et al. (2016) Physiol. Rep. 4, e12731.
- Nieves-Cintrón, M. et al. (2015) J. Biol. Chem. 290, 7918.
- Tsantoulas, C. et al. (2014) Exp. Neurol. 251, 115.
- Fox, P.D. et al. (2013) J. Neurosci. 33, 1259.
- Bocksteins, E. et al. (2012) Am. J. Physiol. 303, C406.
- Tsantoulas, C. et al. (2012) J. Neurosci. 32, 17502.
- Guan, D. et al. (2011) J. Neurophysiol. 106, 1722.