Overview
Cat #:
Size:
10 mg
Lot:
V105SM0110
Alternative Name CP-526,555, Chantix®, Champix®
Lyophilized Powder yes
Source Synthetic
MW: 361.3
Purity: >99% (HPLC)
Effective concentration 1-100 μM.
Structure
Chemical name 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate.
Molecular formula C13H13N3*C4H6O6.
CAS No.: 375815-87-5
Activity Varenicline tartrate is a partial agonist of α4/β2 nicotinic acetylcholine receptors and a full agonist of α7 nAChR1, and may be suitable for treating nicotine addiction2.
References-Activity
- Mihalak, K.B. et al. (2006) Mol. Pharmacol. 70, 801.
- De Biasi, M. and Salas, R. (2008) Exp. Biol. Med. 233, 917.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or six months at -20°C.
Our bioassay
- Alomone Labs Varenicline tartrate activates α7 nicotinic acetylcholine receptor channels heterologously expressed in Xenopus oocytes.Current traces of α7 nicotinic acetylcholine receptor channels activity at -60 mV holding potential. 100 μM Varenicline tartrate (#V-105) alone activates a transient relatively small current (right), while perfusing PNU-120596 prior to Varenicline tartrate activates a much larger current (left), even at a 10 fold lower concentration (middle). Periods of compound perfusion are indicated by the horizontal bars: PNU; PNU-120596, VAR; Varenicline tartrate.
Target α4/β2, α7 nAChR
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations