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Veratridine

An Enhancer of NaV Channel Activity and an Inducer of Transmitter Release

Cat #: V-110
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Veratrum officinale.
    Source Natural
    MW: 673.8
    Purity: >98%
    Effective concentration 1-200 μM.
    Structure
    Chemical name 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol.
    Molecular formula C36H51NO11.
    CAS No.: 71-62-5
    Activity Veratridine is an alkaloid which is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability3.
    References-Activity
    1. Catterall, W.A. (1975) J. Biol. Chem. 250, 4053.
    2. Blaustein, M.P. (1975) J. Physiol. 247, 617.
    3. Wang, G.K. and Wang, S.Y. (2003) J. Physiol. 548, 667.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Veratridine modulates NaV1.4 Na+ currents in Xenopus oocytes.
      Alomone Labs Veratridine modulates NaV1.4 Na+ currents in Xenopus oocytes.
      A. Superimposed example current traces of NaV1.4 channels before (black) and during application of 100 μM Veratridine (#V-110), (green). Note that the current is inhibited during the peak, but is enhanced at its end and especially once the membrane potential is back to rest (tail). B. Time course of NaV1.4 channel activity (measured at the tail current) before and during applications of 100 μM Veratridine (green) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV.
    References - Scientific background
    1. Catterall, W.A. (1975) J. Biol. Chem. 250, 4053.
    2. Blaustein, M.P. (1975) J. Physiol. 247, 617.
    3. Wang, G.K. and Wang, S.Y. (2003) J. Physiol. 548, 667.
    4. Farrag, K.J. et al. (2007) Pflugers Arch. Eur. J. Physiol. 455, 929.
    5. Westphalen, R.I. et al. (2011) Neuropharmacology 61, 699.
    Scientific background Veratridine is an alkaloid extracted from the Veratrum officinale plant. It is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability of NaV1.4 channels expressed in a mammalian cell line3. Veratridine affects differentially the TTX-sensitive and TTX-resistant components of NaV currents in rat DRG neurons. Although veratridine inhibits both components at the peak current, it is much more effective in increasing the persistent component (channel opening) of the TTX-sensitive current4. Veratridine is widely used in different excitable preparations to induce NaV channel dependent transmitter release (see for example reference #5).
    Target Various NaV Na+ channels
    Lyophilized Powder
    Last update: 01/09/2021

    Veratridine (#V-110) is a highly pure, natural, and biologically active compound.

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    For research purposes only, not for human use

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    Citations

    Citations
    Product citations
    1. Deuis, J.R. et al. (2016) Toxins 8, 78.

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