New products are here for those of you working in neuro, immunology, and membrane protein fields.
It’s not every day there’s a new antibody against a new ion channel plus a whole new group of GPCR products, but today is one of those days.
Proton-Activated Chloride Channels
You can now get a primary antibody against proton-activated Cl- channel 1 (PACC1), also known as TMEM206. This channel has been known for quite a while but was only described formally in 2019 when it was found to respond to extracellular acidic pH at which point it imports chloride ions (Yang et al., 2019; Ullrich et al., 2019).
Our Anti-PACC1/TMEM206 (extracellular) Antibody (#ACL-031) targets the extracellular epitope (peptide (C)KLKHPVMSVSYKEVDR, which corresponds to amino acid residues 95–110 of mouse PACC1) and we’ve tested it in western blot, immunohistochemistry, and flow cytometry. And as with everything, it was designed and made right here at Alomone Labs.
Take a look at some of the data:
Lysophosphatidylserines or Lsyo-PSs, are hydrolysis products phosphatidylserine (PS) and are gathering a lot of interest as a newer form of lysophospholipids with a role in hormone-like signaling. These Lyso-PSs also seem to specifically activate three human G protein-coupled receptors (GPCRs): GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3 (Sugo et al., 2006; Inoue et al., 2012).
Given the sizable number of drugs that target GPCRS, the desire to identify GPCR ligands, and the link between Lyso-PS deregulation and human disease (all reviewed in Shanbhag et al., 2021), we thought Lyso-PS receptors deserved their own product category.
And since these GPCRs are expressed in both the brain and immune system, those of you working in neuroscience or neuroinflammation might be especially interested in what we have:
Something you need that isn’t on the catalog? There’s a good chance we can make it for you. Have a look at our Customer Services and get what your research needs.