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Scorpion-Derived NaV Channel Activators

Scorpion-derived toxins continue to supply a plethora of ion channel modulators.

AaH1 Toxin (#STA-155) is a low molecular weight peptide toxin originally isolated from Androctonus australis scorpion venom. It blocks the fast inactivation phase of voltage-gated Na+ channels. We show the toxin’s activity on NaV1.2 channel currents expressed in Xenopus oocytes.

BmKI Toxin (#STB-100) (Alpha-like toxin BmK-M1) is a peptide toxin originally isolated from Mesobuthus martensii scorpion venom. It is a positive modulator of voltage-gated Na+ channels by inhibiting the inactivation of activated NaV channels. We demonstrated BmKI Toxin activity NaV1.6 channels in Xenopus oocytes.

Tf2 Toxin (#STT-050) is a β-scorpion peptide toxin originally isolated from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 Toxin acts as a specific NaV1.3 channel opener. It shifts human NaV1.3 channel voltage activation towards negative values and effectively opens the channel at resting membrane potentials.