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- Cao, Z. et al. (2014) Toxins 6, 796.
- Alomone Labs BmKI Toxin enhances NaV1.6 channel currents in Xenopus oocytes.A. Representative time course of BmKI Toxin (#STB-100) effect on the normalized area of NaV1.6 channel current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage step to +10 mV every 10 sec and was enhanced by the application of 1 µM BmKI Toxin (green). B. Superimposed traces of NaV1.6 current following application of control (black) and of 1 µM BmKI Toxin (green), taken from the recording in A.
- Cao, Z. et al. (2014) Toxins 6, 796.
- Possani, L.D. et al. (1999) Eur. J. Biochem. 264, 287.
- Rahnama, S. et al. (2017) PLoS One 12, e0173551.
The structure of BmKI Toxin includes a motif consisting of one or two short segments of α‐helix and a triple‐stranded β‐sheet, connected by variable regions forming loops1,2.
There are nine mammalian subtypes of voltage-gated sodium (NaV) channels: NaV1.1–NaV1.9. These channels responsible for propagating action potentials in excitable cells and are important therapeutic targets for numerous pathophysiological conditions such as cardiac arrhythmia, and epilepsy3.
BmKI Toxin (#STB-100) is a highly pure, synthetic, and biologically active peptide toxin.
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