…current7. They also retain LTP and fear memory but show a deficiency in spatial memory23 and show altered pain responses24. Thus the physiological counterpart of α1E channels is still uncertain….
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In Focus: Bradykinin Receptors
GPCR Pathways - Issue No. 4
…B1 receptor activation is sustained makes it an attractive potential target in the development of antagonists as it is involved in pain sensation, inflammation and perhaps diabetes4. Alomone Labs offers…
Better Research, Bad Eggs, and Thoughtful Controls
…second messenger. GPCRs also modulate inwardly rectifying K+ channels (Kir) (GIRK) channels, and so if you use a GPCR agonist you’re also going to affect pain transmission, the subsequent release of…
Nicotinic Acetylcholine Receptor (nAChR) Agonists and Antagonists
…addiction, pain, inflammation, and other medical conditions. nAChR products are essential tools for research focused on understanding the role of nicotinic receptors in various biological processes. Alomone Labs offers a…
Finding Feeling: Biology of Senses Receives Nobel Prize
…hundreds of papers being devoted to studying Piezo channels alone. Painful heat David Julius, at the University of California in San Francisco (UCSF), on the other hand, was looking at…
pro-Neurotrophins: The Other Identity of Neurotrophins
Neurotrophin Pathways - Issue No. 2
…rat sciatic nerve12. Following application of the traditional CCI model of neuropathic pain, mast cells followed by keratinocytes and vascular endothelium upregulated proNGF, up to four weeks post-injury, as confirmed…
The Molecular Diversity of TRP Channels and Related Proteins
Modulator - Issue No. 16
…non-selective Ca2+-permeable channels activated by heat and other pain-producing stimuli40. Other members of this family, TRPV6 (CaT1, ECaC)41,42 and TRPV5 (CaT2)43, seem to be involved in Ca2+ transport in epithelial…
The Molecular Diversity of TRPC Channels and Related Proteins
Modulator - Issue No. 13
…non-selective Ca2+-permeable channels activated by heat and other pain-producing stimuli35. Other members of this family, CaT1 (ECaC)30,31 and CaT239, seem to be involved in Ca2+ transport in epithelial cells32. The…
NT-3 and NT-4 at the Nerve Center of Neurotrophic Research
Neurotrophin Pathways - Issue No. 2
…Brigadski, T. et al. (2005) J. Neurosci. 25, 7601. Cohen, S. et al. (1954) Proc. Natl. Acad. Sci. U.S.A. 40, 1014. Connor, M. et al. (2005) Mol. Pain 1, 31….
In Focus: Piezo Channels
Modulator - Issue No. 27
Mechanical stimulus is the driving force for numerous physiological processes including pain sensation, hearing, and blood pressure regulation2. Piezo1 and Piezo2 were first characterized in a mouse neuroblastoma cell line,…
Bioz: More Data, More Citations, Better Decisions
…putting trust into it becomes a lot easier. It’s just that, quite often, that data’s a pain to find. Even if a vendor has a link to papers the reagent’s…