Anoctamin Family

Anoctamin (ANO, or TMEM16) is a family of membrane proteins which includes 10 members. This family is named so because these channels selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini. Members of this family are expressed in a broad range of different organisms ranging from mammals, flies, worms, plants as well as yeast. Alternative splicing is known to affect these channels and regarding their oligomerization state, homedimerization has been observed although when heterologously expressed, these channels may hetero oligomerize.