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Ca2+ Signaling Pharmacology

Ca2+ can influence various cellular outcomes by either entering the cell from the extracellular milieu or by being released from intracellular stores, such as the endoplasmic reticulum (ER). Ca2+ release from the ER is influenced by a number of factors like the activation of G-protein coupled receptors and receptor tyrosine kinases which activate downstream pathways leading to Ca2+ release. There are also membrane proteins located on the ER membrane which are known to influence Ca2+ release. Such proteins include IP3R, ryanodine receptors (RyRs) and various pumps. Many compounds can either promote or inhibit Ca2+ release from the ER.