HCN Antibody Explorer Kit

A Screening Package of HCN Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • QC Tested
  • Shipped at Room Temp.
Cat #: AK-205
Sizes: 14 Vials
Last update: 25/12/2017

Alomone Labs is pleased to offer the HCN Antibody Explorer Kit (#AK-205). The Explorer Kit contains HCN antibodies with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-HCN1
APC-056 1 x 50 µl
Guinea pig Anti-HCN1
AGP-203 1 x 50 µl
Anti-HCN2
APC-030 1 x 50 µl
Anti-HCN3
APC-057 1 x 50 µl
Anti-HCN3 (extracellular)
APC-083 1 x 50 µl
Anti-HCN4
APC-052 1 x 50 µl
Guinea pig Anti-HCN4
AGP-004 1 x 50 µl
Note Guinea pig polyclonal antibodies (#AGP-203 & #AGP-004) are included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and have a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity1,2.

The Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated channel family (HCN), which is comprised of four homologous members, HCN1-4.

Each HCN subunit consists of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain for cyclic nucleotides (CNBD) in the cytoplasmic C-terminus2. The HCN subunits can form functional homomers and can also co-assemble into functionally heteromers2.

The channels are closely related to each other and share a homology of about 60%. However, their similarity decreases in the cytoplasmic N- and C-termini. The channels HCN1-4 mainly differ from each other in their speed of activation and the extent to which they are modulated by cAMP. HCN1, weakly affected by cAMP, is the fastest channel, followed by HCN2, HCN3 and HCN4.

References
  1. Hughes, D.I. et al. (2012) J. Physiol. 590.16, 3927.
  2. Klueva, J. et al. (2012) Neurosignals 20, 35.
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