This product is freeze dried. All water molecules have been removed.
This antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the Kir Channel Blocker Explorer Kit (#EK-112). The Explorer Kit contains many classical Kir channel blockers, ideal for screening purposes.
Kir1.1 (ROMK1) was the first member of the family of inward rectifying K+ channels to be cloned1. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunits that can assemble as either homo- or hetero-tetramers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis2.