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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the Kir Channel Blocker Explorer Kit (#EK-112). The Explorer Kit contains many classical Kir channel blockers, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Carvedilol | C-180 | 1 x 50 mg |
δ-Dendrotoxin | D-380 | 1 x 70 µg |
Lq2 | RTL-550 | 1 x 5 µg |
Rosiglitazone | R-125 | 1 x 10 mg |
Tertiapin | STT-250 | 1 x 0.1 mg |
Tertiapin-LQ | STT-220 | 1 x 0.5 mg |
Tertiapin-Q | STT-170 | 1 x 0.1 mg |
VU590 dihydrochloride | V-130 | 1 x 5 mg |
VU591 hydrochloride | V-126 | 1 x 5 mg |
Scientific Background
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Kir1.1 (ROMK1) was the first member of the family of inward rectifying K+ channels to be cloned1. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunits that can assemble as either homo- or hetero-tetramers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis2.
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