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Kir Channel Blocker Explorer Kit

A Screening Package of Kir Channel Blockers Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-112
Sizes: 9 Vials
Last update: 24/04/2019

Alomone Labs is pleased to offer the Kir Channel Blocker Explorer Kit (#EK-112). The Explorer Kit contains many classical Kir channel blockers, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Carvedilol
 		C-180 1 x 50 mg
δ-Dendrotoxin
 		D-380 1 x 70 µg
Lq2
 		RTL-550 1 x 5 µg
Rosiglitazone
 		R-125 1 x 10 mg
Tertiapin
 		STT-250 1 x 0.1 mg
Tertiapin-LQ
 		STT-220 1 x 0.5 mg
Tertiapin-Q
 		STT-170 1 x 0.1 mg
VU590 dihydrochloride
 		V-130 1 x 5 mg
VU591 hydrochloride
 		V-126 1 x 5 mg
References

    • Kir1.1 (ROMK1) was the first member of the family of inward rectifying K+ channels to be cloned1. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.

      The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunits that can assemble as either homo- or hetero-tetramers.

      Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis2.
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