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Intracellular Ca2+ Modulator Explorer Kit

A Screening Package of Intracellular Ca2+ Modulators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-100
Sizes: 22 Vials
Last update: 15/04/2019

Alomone Labs is pleased to offer the Intracellular Ca2+ Modulator Explorer Kit (#EK-100). This Explorer Kit includes various small molecules and peptides known to modulate Ca2+ release from intracellular stores, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
A23187
 		A-600 1 x 1 mg
Anhydroryanodine
 		A-510 1 x 50 µg
BAPTA-AM
 		B-180 1 x 2 mg
(±)-Bay K8644
 		B-350 1 x 5 mg
Caffeine
 		C-395 1 x 500 mg
Cyclopiazonic Acid
 		C-750 1 x 5 mg
Dantrolene sodium salt
 		D-185 1 x 5 mg
Imperatoxin A
 		I-300 1 x 5 µg
Ionomycin calcium salt
 		I-700 1 x 1 mg
L-IP3
 		L-250 1 x 0.1 mg
Loperamide hydrochloride
 		L-100 1 x 5 g
Maurocalcine
 		RTM-100 1 x 0.1 mg
Miconazole nitrate
 		M-206 1 x 1 g
Neomycin sulfate
 		N-305 1 x 50 mg
Ochratoxin A
 		O-400 1 x 0.5 mg
Paxilline
 		P-450 1 x 0.45 mg
Ruthenium red
 		R-175 1 x 5 mg
Ryanodine
 		R-500 1 x 0.5 mg
tBuBHQ
 		T-220 1 x 250 mg
Thapsigargin
 		T-650 1 x 0.65 mg
Thapsigargin Epoxide
 		T-670 1 x 50 µg
TMB-8 hydrochloride
 		T-245 1 x 5 mg
References
Scientific Background

Ca2+ can influence various cellular outcomes by either entering the cell from the extracellular milieu or by being released from intracellular stores, such as the endoplasmic reticulum (ER). Ca2+ release from the ER is influenced by a number of factors like the activation of G-protein coupled receptors and receptor tyrosine kinases which activate downstream pathways leading to Ca2+ release. There are also membrane proteins located on the ER membrane which are known to influence Ca2+ release. Such proteins include IP3R, ryanodine receptors (RyRs) and various pumps. Many compounds can either promote or inhibit Ca2+ release from the ER.
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