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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the Intracellular Ca2+ Modulator Explorer Kit (#EK-100). This Explorer Kit includes various small molecules and peptides known to modulate Ca2+ release from intracellular stores, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
A23187 | A-600 | 1 x 1 mg |
Anhydroryanodine | A-510 | 1 x 50 µg |
BAPTA-AM | B-180 | 1 x 2 mg |
(±)-Bay K8644 | B-350 | 1 x 5 mg |
Caffeine | C-395 | 1 x 500 mg |
Cyclopiazonic Acid | C-750 | 1 x 5 mg |
Dantrolene sodium salt | D-185 | 1 x 5 mg |
Imperatoxin A | STI-333 | 1 x 0.1 mg |
Ionomycin calcium salt | I-700 | 1 x 1 mg |
L-IP3 | L-250 | 1 x 0.1 mg |
Loperamide hydrochloride | L-100 | 1 x 5 g |
Maurocalcine | RTM-100 | 1 x 0.1 mg |
Miconazole nitrate | M-206 | 1 x 1 g |
Neomycin sulfate | N-305 | 1 x 50 mg |
Ochratoxin A | O-400 | 1 x 0.5 mg |
Paxilline | P-450 | 1 x 0.45 mg |
Ruthenium red | R-175 | 1 x 5 mg |
Ryanodine | R-500 | 1 x 0.5 mg |
tBuBHQ | T-220 | 1 x 250 mg |
Thapsigargin | T-650 | 1 x 0.65 mg |
Thapsigargin Epoxide | T-670 | 1 x 50 µg |
TMB-8 hydrochloride | T-245 | 1 x 5 mg |
Scientific Background
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Ca2+ can influence various cellular outcomes by either entering the cell from the extracellular milieu or by being released from intracellular stores, such as the endoplasmic reticulum (ER). Ca2+ release from the ER is influenced by a number of factors like the activation of G-protein coupled receptors and receptor tyrosine kinases which activate downstream pathways leading to Ca2+ release. There are also membrane proteins located on the ER membrane which are known to influence Ca2+ release. Such proteins include IP3R, ryanodine receptors (RyRs) and various pumps. Many compounds can either promote or inhibit Ca2+ release from the ER.
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