Overview
Alomone Labs is pleased to offer the Intracellular Ca2+ Modulator Explorer Kit (#EK-100). This Explorer Kit includes various small molecules and peptides known to modulate Ca2+ release from intracellular stores, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
A23187 |
A-600 | 1 x 1 mg |
Anhydroryanodine |
A-510 | 1 x 50 µg |
BAPTA-AM |
B-180 | 1 x 2 mg |
(±)-Bay K8644 |
B-350 | 1 x 5 mg |
Caffeine |
C-395 | 1 x 500 mg |
Cyclopiazonic Acid |
C-750 | 1 x 5 mg |
Dantrolene sodium salt |
D-185 | 1 x 5 mg |
Imperatoxin A |
STI-333 | 1 x 0.1 mg |
Ionomycin calcium salt |
I-700 | 1 x 1 mg |
Maurocalcine |
RTM-100 | 1 x 0.1 mg |
Ochratoxin A |
O-400 | 1 x 0.5 mg |
Paxilline |
P-450 | 1 x 0.45 mg |
Ruthenium red |
R-175 | 1 x 5 mg |
Ryanodine |
R-500 | 1 x 0.5 mg |
tBuBHQ |
T-220 | 1 x 250 mg |
Thapsigargin |
T-650 | 1 x 0.65 mg |
Thapsigargin Epoxide |
T-670 | 1 x 50 µg |
TMB-8 hydrochloride |
T-245 | 1 x 5 mg |
Scientific Background
Ca2+ can influence various cellular outcomes by either entering the cell from the extracellular milieu or by being released from intracellular stores, such as the endoplasmic reticulum (ER). Ca2+ release from the ER is influenced by a number of factors like the activation of G-protein coupled receptors and receptor tyrosine kinases which activate downstream pathways leading to Ca2+ release. There are also membrane proteins located on the ER membrane which are known to influence Ca2+ release. Such proteins include IP3R, ryanodine receptors (RyRs) and various pumps. Many compounds can either promote or inhibit Ca2+ release from the ER.
