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Frizzled Receptors

Frizzled receptors (FZD) belong to the super family of G-protein coupled receptors (GPCR). They are classified to the frizzled subfamily for which 11 members have been identified to date; FZD1-10 and Smoothened. They were first identified in Drosophila melanogaster.
Like all GPCRs, Frizzled receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. However, these receptors lack many features of the conventional class A, B or C GPCRs.