Overview
Alomone Labs is pleased to offer the TTX-Resistant NaV Channel Antibody Explorer Kit (#AK-223). This Explorer Kit includes antibodies targeted against voltage-gated Na+ channels along with their respective peptide control antigen. An ideal tool for screening purposes.
Compounds
Scientific Background
Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow the flow of Na+ ions.
To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.
- Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291.
- Fang, X. et al. (2002) J. Neurosci. 22, 7425.
- Wu, L. et al. (2002) Neuro. Report. 13, 2547.
- Baker, M.D. and Wood, J.N. (2001) Trends. Pharmacol. Sci. 22, 27.
- Fjell, J. et al. (2000) Neuro. Report. 11, 199.
