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Endothelin Receptor Agonist Explorer Kit

A Screening Package of Endothelin Receptor Agonists Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-255
Sizes: 4 Vials
Last update: 24/04/2019

Alomone Labs is pleased to offer the Endothelin Receptor Agonist Explorer Kit (#EK-255). The Explorer Kit contains endothelin receptor agonists, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
BQ-3020
 		SPE-200 1 x 5 mg
[Ala1,3,11,15] Endothelin-1
 		SPE-240 1 x 5 mg
IRL-1620
 		SPE-220 1 x 5 mg
Sarafotoxin S6b
 		SPE-160 1 x 0.1 mg
References

    • The endothelin system is comprised of three active peptides, ET-1, 2, and 3, which are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein Coupled Receptors, ETAR and ETBR. Both ETAR and ETBR are present in heart and in human myocardium at similar levels.1,2

      The endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity.2,3 Subsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities.
      1. Boivin, B. et al. (2003) J. Biol.Chem. 278, 29153.
      2. Grant, K. et al. (2003) Br. J. Cancer. 88, 163.
      3. Davenport, A.P. (2002) Pharmacol. Rev. 54, 219.
      4. Asham, E. et al. (2001) Br. J. Cancer. 85, 1759.
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