Live Cell Imaging Products

Extracellular antibodies are ideal research tools for cell-surface proteins.

 

No permeabilization/fixation because using extracellular antibodies allows you to work with live cells!

 

Benefits of live cell imaging:
Monitor cell movement
Study protein transport across the cell
Investigate protein internalization

NaV1.7 Channels

NaV1.7  (Scn9a) is predominantly expressed in dorsal root ganglions (DRG) of the peripheral nervous system. Dominant gain-of-function mutations in the NaV1.7 gene are associated with erythermalgia (a rare autosomal disease characterized by sporadic burning pain accompanied by redness and heat in the extremities). Loss-of-function mutations in NaV1.7 channels, lead to complete ablation of pain perception in humans. Scn9a is a major therapeutic target for pain.