The mammalian TRP channel superfamily includes nearly 30 members which are distributed in several subfamilies: TRPC (classic or canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPP (polycistin), and TRPML (mucolipin). Each subfamily comprises several channel subtypes, and many have splice variants, leading to the exhaustive list of channels and their pairing combination. The TRP channels are a superfamily of channels that allow the influx of both Ca²⁺ and Na⁺.