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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the KV2 Channel Blocker Explorer Kit (#EK-220). The Explorer Kit contains KV2 channel blockers, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Citalopram hydrobromide | C-185 | 1 x 25 mg |
Guangxitoxin-1E | STG-200 | 1 x 0.1 mg |
Jingzhaotoxin-III | STJ-200 | 1 x 50 µg |
Jingzhaotoxin-IX | STJ-300 | 1 x 50 µg |
ProTx-I | STP-400 | 1 x 50 µg |
Stromatoxin-1 | STS-350 | 1 x 50 µg |
Scientific Background
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KV2.2 is a member of the voltage-gated K+ channel superfamily. Together with the closely related KV2.1 protein they form the KV2 subfamily also known as Shab1-3.
As with all KV channels, KV2.2 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functional KV channel is a tetramer that can either be a homotetramer or a heteromer of KV2.2 and KV2.1 subunits1-3.
The pharmacology of the KV2.2 channel is somewhat limited. The channel is blocked by the classical K+ channel blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP). More recently, the small peptide toxin Stromatoxin-1 has been found to be a potent and more specific inhibitor of the KV2 subfamily4.
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