K_V2 Channel Blocker Explorer Kit

K_V2.2 is a member of the voltage-gated K⁺ channel superfamily. Together with the closely related K_V2.1 protein they form the K_V2 subfamily also known as Shab^1-3.

As with all K_V channels, K_V2.2 possesses the signature structure of the voltage-dependent K⁺ channels: six membrane-spanning domains with intracellular N and C termini. The functional K_V channel is a tetramer that can either be a homotetramer or a heteromer of K_V2.2 and K_V2.1 subunits^1-3.

The pharmacology of the K_V2.2 channel is somewhat limited. The channel is blocked by the classical K⁺ channel blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP). More recently, the small peptide toxin Stromatoxin-1 has been found to be a potent and more specific inhibitor of the K_V2 subfamily⁴.