Neuroscience

Neuroscience

Reagents for ion channels, neurotransmitter receptors, and neural signaling pathways

In-house made and tested antibodies, peptides, ligands, and toxins for studies involving neuronal excitability, synaptic transmission, receptor signaling, and sensory pathways. Popular targets include ion channels (voltage-gated, TRP, ASIC), GPCRs (G-protein–coupled receptors), neurotransmitter receptors, and neuropeptides. All reagents are validated in multiple approaches, including immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB), flow cytometry, electrophysiology, or live-cell assays.

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Neurodegenerative Diseases
Neurodegenerative Diseases
Neuroinflammation
Neuroinflammation
Psychiatric Disorders
Psychiatric Disorders
Pain
Pain
Stroke
Stroke
Epilepsy
Epilepsy
Neuroimmunology
Neuroimmunology
Neuroplasticity
Neuroplasticity
Synaptic Function
Synaptic Function
Neurodevelopment
Neurodevelopment
Microglia Markers
Microglia Markers

FAQs

View all FAQs >

If you can’t find the answer, please contact us.

  • The blocking peptide is the antigen we use for immunization during antibody generation so that we can create an antigen-specific antibody. You can use this blocking peptide as a negative control alongside other controls in an immunoassay to give some insight into antibody specificity, but not selectivity.

    It’s important to note that the blocking peptide is not an effective control for use with live cells. If you need a control for flow cytometry, we recommend an isotype antibody control instead.

    For more details, see our guide to blocking peptides.

  • We carefully choose the epitope for immunization, taking into account two main parameters: immunogenicity and specificity of the epitope.

    Before immunization, we run a search to verify that the chosen epitope has maximum homology with other species and minimum homology among members of the same family or other proteins. After immunization and collection of sera, the antibodies are affinity-purified on immobilized antigens (the injected peptides).

    This means you shouldn’t have to worry about your antibody cross-reacting with close members of the same protein family.

  • Affinity-purified rabbit polyclonal antibodies are mainly IgGs.

  • Your antibody comes as a lyophilized powder in phosphate-buffered saline (PBS), (pH 7.4), with 1% BSA, and 0.05% NaN3. Before you reconstitute the antibody, we recommend you briefly centrifuge the vial to ensure all of the antibody is at the bottom of the tube. You can then reconstitute the antibody in double-distilled water (DDW) or any other water that you prefer (such as UltraPure DNase/RNase-Free Water). Note: the volume of water that you should add to reconstitute the antibody is shown on the vial. After reconstitution, you can further dilute the antibody to the recommended working concentration with any desired buffer.

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240 Results
  • AP-18
    Bioassay Tested
    AP-18
    A Reversible TRPA1 Channel Blocker
    • Product Code: A-250
    • Short Description: A Reversible TRPA1 Channel Blocker
    • CAS No.: 55224-94-7
    • MW: 209.7
  • APETx2
    Bioassay Tested
    APETx2
    A potent blocker of ASIC3 and moderate blocker of NaV1.8 channels
    • Product Code: STA-160
    • Short Description: A potent blocker of ASIC3 and moderate blocker of NaV1.8 channels
    • Applications: Electrophysiology
    • CAS No.: 713544-47-9
    • MW: 4561 Da
  • Arvanil
    Bioassay Tested
    Arvanil
    An Agonist of TRPV1 Channels and a Ligand of CB1 Receptors
    • Product Code: A-335
    • Short Description: An Agonist of TRPV1 Channels and a Ligand of CB1 Receptors
    • CAS No.: 128007-31-8
    • MW: 439.64
  • ASIC3 Blocking Peptide
    ASIC3 Blocking Peptide
    A Blocking Peptide for Anti-ASIC3 Antibody
    • Product Code: BLP-SC018
    • Short Description: A Blocking Peptide for Anti-ASIC3 Antibody
    • Applications: Western blot, Immunohistochemistry
    • Target: ASIC3
  • ATX-II
    Bioassay Tested
    ATX-II
    A potent activator of voltage-gated sodium NaV channels that primarily targets cardiac NaV1.5 channels by delaying their fast inactivation
    • Product Code: STA-700
    • Short Description: A potent activator of voltage-gated sodium NaV channels that primarily targets cardiac NaV1.5 channels by delaying their fast inactivation
    • Applications: Electrophysiology
    • CAS No.: 60748-45-0
    • MW: 4935 Da
  • Azasetron hydrochloride
    Bioassay Tested
    Azasetron hydrochloride
    A Potent Antagonist of Serotonin-Gated Channels
    • Product Code: Y-100
    • Short Description: A Potent Antagonist of Serotonin-Gated Channels
    • CAS No.: 123040-16-4
    • MW: 386.3
  • BCTC
    Bioassay Tested
    BCTC
    A Potent Antagonist of TRPV1 and TRPM8 Channels
    • Product Code: B-110
    • Short Description: A Potent Antagonist of TRPV1 and TRPM8 Channels
    • CAS No.: 393514-24-4
    • MW: 372.9
  • BDS-I
    Bioassay Tested
    BDS-I
    A blocker of KV potassium channels and a modulator that slows the inactivation of NaV sodium channels (particularly NaV1.7)
    • Product Code: STB-400
    • Short Description: A blocker of KV potassium channels and a modulator that slows the inactivation of NaV sodium channels (particularly NaV1.7)
    • Applications: Electrophysiology
    • CAS No.: 207621-38-3
    • MW: 4708 Da
  • BDS-II
    Bioassay Tested
    BDS-II
    A potent gating modifier/blocker of KV3 potassium channels and a modulator of NaV1.7 sodium channels
    • Product Code: B-450
    • Short Description: A potent gating modifier/blocker of KV3 potassium channels and a modulator of NaV1.7 sodium channels
    • Applications: Electrophysiology
    • MW: 4776.4 Da
  • Benzamil
    Bioassay Tested
    Benzamil
    An Inhibitor of Na+/Ca2+ Exchangers and a Blocker of ASIC, TRPP3 and TRPA1 Channels
    • Product Code: B-161
    • CAS No.: 161804-20-2
    • MW: 319.75
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FAQs

View all FAQs >

If you can’t find the answer, please contact us.

  • The blocking peptide is the antigen we use for immunization during antibody generation so that we can create an antigen-specific antibody. You can use this blocking peptide as a negative control alongside other controls in an immunoassay to give some insight into antibody specificity, but not selectivity.

    It’s important to note that the blocking peptide is not an effective control for use with live cells. If you need a control for flow cytometry, we recommend an isotype antibody control instead.

    For more details, see our guide to blocking peptides.

  • We carefully choose the epitope for immunization, taking into account two main parameters: immunogenicity and specificity of the epitope.

    Before immunization, we run a search to verify that the chosen epitope has maximum homology with other species and minimum homology among members of the same family or other proteins. After immunization and collection of sera, the antibodies are affinity-purified on immobilized antigens (the injected peptides).

    This means you shouldn’t have to worry about your antibody cross-reacting with close members of the same protein family.

  • Affinity-purified rabbit polyclonal antibodies are mainly IgGs.

  • Your antibody comes as a lyophilized powder in phosphate-buffered saline (PBS), (pH 7.4), with 1% BSA, and 0.05% NaN3. Before you reconstitute the antibody, we recommend you briefly centrifuge the vial to ensure all of the antibody is at the bottom of the tube. You can then reconstitute the antibody in double-distilled water (DDW) or any other water that you prefer (such as UltraPure DNase/RNase-Free Water). Note: the volume of water that you should add to reconstitute the antibody is shown on the vial. After reconstitution, you can further dilute the antibody to the recommended working concentration with any desired buffer.

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