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Issue No. 24

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Alomone Labs: Twenty Years of Ion Channel Activity

Alomone Labs was established in 1989, and has since grown to be a leading company specialized in the field of ion channel research tools. The activities of Alomone Labs include the generation of novel and specific ion channel, GPCR and neurotrophic factor antibodies as well as the recombinant …


Aquaporins: the Waterways of Nature

The importance of the Aquaporin water channels was underscored by awarding the 2003 Nobel Prize in Chemistry to Peter Agre “for the discovery of water channels”. Many scientific articles have been published describing the Aquaporins’ structure, function and tissue distribution. Among the many …


Voltage-Gated Na+ Channels in the CNS

Voltage-gated Na+  channels are membrane proteins that are essential for the generation and propagation of action potentials in excitable tissues, such as brain, muscle, and heart following membrane depolarization. These channels are heteromultimeric protein complexes consisting of one α and one …


Tickling the Heart and the Nervous System with the Funny Current

Since their discovery in sinoatrial node cells and neurons in the late 1970s and early 1980s, Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channels have sparked continuing interests. The use of Alomone Labs antibodies directed towards HCN channels provides an extensive research tool …


Cl Channels Come into Focus

Cl-  channels are involved in several physiological functions ranging from epithelial fluid regulation to skeletal muscle contractibility. They are also involved in a number of human diseases including cystic fibrosis and Bartter’s syndrome among others. Mammalian Cl-  channels can be broadly …