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α-Conotoxin AuIA

An Antagonist of α3/β4 nAChR

Cat #: STC-960
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 1726 Da
    Purity: >98% (HPLC)
    Effective concentration 5 -20 µM.
    Sequence GCCSYPPCFATNSDYC.
    Modifications Disulfide bonds between Cys2-Cys8 and Cys3-Cys16. C-terminal Cys16 amidation.
    Structure
    Molecular formula C72H100N18O24S4.
    Activity α-Conotoxin AuIA is a blocker of α3/β4 nAChR subtypes1.
    References-Activity
    1. Luo, S. et al. (1998) J. Neurosci. 18, 8571.
    Accession number P56639.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs α-Conotoxin AuIA inhibits α3/β4 nAChR channels heterologously expressed in Xenopus oocytes.
      Alomone Labs α-Conotoxin AuIA inhibits α3/β4 nAChR channels heterologously expressed in Xenopus oocytes.
      Trace of α3/β4 nAChR channel current in the absence and presence of α-Conotoxin AuIA (#STC-960). Current amplitudes were plotted as a function of time. Membrane potential was held at -80 mV and oocytes were stimulated by exposure to 1 μM ACh (top bar). α3/β4 nAChR currents are inhibited by 2 min application of 20 µM α-Conotoxin-AuIA (green, bottom bar).
    References - Scientific background
    1. Janes, R.W. et al. (2005) Curr. Opin. Pharmacol. 5, 280.
    2. Luo, S. et al. (1998) J. Neurosci. 18, 8571.
    Scientific background Small peptide toxins of Conus origin are highly useful tools for exploring ligand nicotinic acetylcholine receptors (nAChRs) interactions1. There are three α-conotoxin AuIs found in Conus aulicus: AuIA, AuIB and AuIC. α-Conotoxin AuIA is a 16 amino acid peptidyl toxin, belonging to neuronal α 4/7 subfamily of α-conotoxins. This toxin inhibits mammalian neuronal α3/β4 nicotinic acetylcholine receptor channels expressed in Xenopus oocytes. At relatively low concentrations (0.3 and 1.0 μM), this conotoxin is selective and inhibits only α3/β4 subtypes2.
    Target α3/β4 nAChR
    Net Peptide Content: 100%
    Lyophilized Powder
    Last update: 08/06/2021

    α-Conotoxin AuIA (#STC-960) is a highly pure, synthetic, and biologically active peptide toxin.

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    For research purposes only, not for human use
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