α-Conotoxin ImI

α-CTx ImI
A Potent Antagonist of Mammalian α3/β2 Neuronal nAChR
    Cat #: C-290
    Alternative Name α-CTx ImI
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1351 Da.
    Purity: >99% (HPLC)
    Effective concentration 0.1-10 μM.
    Sequence GCCSDPRCAWRC.
    Modifications Disulfide bonds between Cys2-Cys8 and Cys3-Cys12. Cys12 - C-terminal amidation.
      • α-Conotoxin ImI
    Molecular formula C52H78N20O15S4.
    CAS No.: 156467-85-5.
    Activity α-Conotoxin ImI potently and specifically blocks mammalian neuronal nAChR (α3/β2 > α7 > α3/β4)1.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
      • α-Conotoxin ImI
        Alomone Labs α-Conotoxin ImI inhibits α3/β2 nAChR channels heterologously expressed in Xenopus oocytes.
        Time course of α-Conotoxin ImI (#C-290) action on α3/β2 nAChR channels. Current amplitudes were plotted as a function of time. Membrane potential was held at –80 mV and oocytes were stimulated by exposure to 10 nM acetylcholine and 10 μM atropine for 5 seconds every 100 seconds. The indicated α-CTx ImI concentrations (inset) were perfused during the period marked by color.
    References - Scientific background
      • α-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom1, which blocks mammalian neuronal nAChRs located on postsynaptic membranes. This toxin inhibits mammalian neuronal nAChRs (α3/β2 > α7 > α3/β4) in a voltage-independent manner and has no effect on nAChRs composed of α2/β2, α3/β2, α4/β2, α2/β4, α3/β4, or α4/β4 subunits1,2.
    Target α3/β2 nAChR
    Net Peptide Content: 100%
    Last update: 08/09/2019

    α-Conotoxin ImI (#C-290) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use