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α-Conotoxin ImI

α-CTx ImI

A Potent Antagonist of Mammalian α3/β2 Neuronal nAChR

Cat #: C-290
Alternative Name α-CTx ImI
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 1351 Da
    Purity: >99% (HPLC)
    Effective concentration 0.1-10 μM
    Sequence GCCSDPRCAWRC
    Modifications Disulfide bonds between Cys2-Cys8 and Cys3-Cys12. Cys12 - C-terminal amidation.
    Structure
    Molecular formula C52H78N20O15S4.
    CAS No.: 156467-85-5
    Activity α-Conotoxin ImI potently and specifically blocks mammalian neuronal nAChR (α3/β2 > α7 > α3/β4)1.
    References-Activity
    1. McIntosh, J.M. et al. (1994) J. Biol. Chem. 269, 16733.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs α-Conotoxin ImI inhibits α3/β2 nAChRs expressed in Xenopus oocytes.
      Alomone Labs α-Conotoxin ImI inhibits α3/β2 nAChRs expressed in Xenopus oocytes.
      A. Representative time course of α3/β2 current inhibition by 100 nM (green) and 1 µM (magenta) α-Conotoxin ImI (#C-290). Currents were elicited every 50 sec by transient applications of 2 µM ACh, while membrane potential was held at -60 mV, and inhibited by 100nM and 1 µM α-Conotoxin ImI.
      B. Superimposed traces of α3/β2 currents evoked by ACh (arrow) after application of control (black), 100nM (green) and 1 µM (magenta) α-Conotoxin ImI (Taken from the recording in A).
    References - Scientific background
    1. McIntosh, J.M. et al. (1994) J. Biol. Chem. 269, 16733.
    2. Johnson, D.S. et al. (1995) Mol. Pharmacol. 48, 194.
    Scientific background α-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom1, which blocks mammalian neuronal nAChRs located on postsynaptic membranes. This toxin inhibits mammalian neuronal nAChRs (α3/β2 > α7 > α3/β4) in a voltage-independent manner and has no effect on nAChRs composed of α2/β2, α3/β2, α4/β2, α2/β4, α3/β4, or α4/β4 subunits1,2.
    Target α3/β2 nAChR
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 02/01/2022

    α-Conotoxin ImI (#C-290) is a highly pure, synthetic, and biologically active peptide toxin.

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    For research purposes only, not for human use
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