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Certificate of Analysis

  • Bioassay Tested

5-HT3 Receptor Modulator Explorer Kit

A Screening Package of 5-HT3 Receptor Modulators Economically Priced

Cat #: EK-209
Size: 22 Vials
Form: Lyophilized

3-AQC Cat #: A-205

Size: 5 mg Source: Synthetic MW: 395.41 Purity: >98%
Effective concentration
1-100 µM.
Activity
3-AQC is a potent and selective 5-HT3A receptor antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Azasetron Cat #: A-240

Size: 5 mg Source: Synthetic MW: 349.8 Purity: >98%
Effective concentration
0.1-100 nM.
Activity
Azasetron is a potent and selective 5-HT3 channel blocker with Ki ~2.9 nM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Azasetron hydrochloride Cat #: Y-100

Size: 5 mg Source: Synthetic MW: 386.3 Purity: >98%
Effective concentration
0.1-100 nM.
Activity
Azasetron hydrochloride is a potent 5-HT3 channel blocker with a Ki ~2.9 nM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Bilobalide Cat #: B-145

Size: 10 mg Source: Natural MW: 326.3 Purity: >99.5%
Origin
Ginkgo biloba.
Effective concentration
1-100 µM.
Activity
Bilobalide is a 5-HT3A1 and GABAA2 channel blocker.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

5-Chloroindole Cat #: C-260

Size: 1 g Source: Synthetic MW: 151.6 Purity: >98%
Effective concentration
1-100 µM.
Activity
5-Chloroindole is a potent and selective allosteric modulator of the 5-HT3 receptor that displays micromolar potency1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Ginkgolide B Cat #: G-170

Size: 10 mg Source: Natural MW: 424.4 Purity: >98%
Origin
Ginkgo biloba.
Effective concentration
500-1000 µM.
Activity
Ginkgolide B is a 5-HT3A channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Lerisetron Cat #: L-175

Size: 5 mg Source: Synthetic MW: 292.4 Purity: >98%
Effective concentration
0.5-100 nM.
Activity
Lerisetron inhibits the 5-HT-induced Bezold-Jarisch reflex in anesthetized rats, pKi = 9.21.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

m-Chlorophenylbiguanide hydrochloride Cat #: M-160

Size: 500 mg Source: Synthetic MW: 248.11 Purity: >99%
Effective concentration
0.1-20 µM.
Activity
m-Chlorophenylbiguanide is an activator/agonist of 5-HT3 channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

MCI-225 Cat #: M-190

Size: 5 mg Source: Synthetic MW: 328.4 Purity: >98%
Effective concentration
10 nM - 1 µM.
Activity
MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

MDL 72222 Cat #: M-155

Size: 10 mg Source: Synthetic MW: 314.2 Purity: >95%
Effective concentration
1 nM - 1µM.
Activity
MDL 72222 is an antagonist of 5-HT3 receptors1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

2-Methyl-5-hydroxytryptamine hydrochloride Cat #: M-170

Size: 5 mg Source: Synthetic MW: 226.7 Purity: >97%
Effective concentration
0.5-50 µM.
Activity
Methyl serotonin is a 5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

1-Phenylbiguanide hydrochloride Cat #: P-190

Size: 1 g Source: Synthetic MW: 213.67 Purity: >99%
Effective concentration
0.1-100 µM.
Activity
1-Phenylbiguanide hydrochloride is an activator of 5-HT3 channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

PU02 Cat #: P-165

Size: 5 mg Source: Synthetic MW: 292.4 Purity: >98%
Effective concentration
0.1-10 µM.
Activity
PU02 is a negative allosteric modulator of 5-HT31.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

RS 56812 hydrochloride Cat #: R-130

Size: 5 mg Source: Synthetic MW: 347.14 Purity: >96%
Effective concentration
1 nM – 1 µM.
Activity
RS 56812 is a highly potent and selective 5-HT3 partial agonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SR 57227A Cat #: S-155

Size: 5 mg Source: Synthetic MW: 248.15 Purity: >96%
Effective concentration
100 nM - 100 µM.
Activity
SR 57227A is a high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SDZ 205-557 hydrochloride Cat #: S-145

Size: 5 mg Source: Synthetic MW: 337.2 Purity: >99%
Effective concentration
100 nM - 10 µM.
Activity
SDZ 205-557 hydrochloride is a 5-HT3 and 5-HT4 receptor antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
65 mg/ml in H2O. 100mg/ml in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Serotonin hydrochloride Cat #: S-165

Size: 100 mg Source: Synthetic MW: 212.7 Purity: >98%
Effective concentration
50 nM - 50 µM.
Activity
Serotonin is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
150 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Talipexole dihydrochloride Cat #: B-140

Size: 5 mg Source: Synthetic MW: 282.23 Purity: >98%
Effective concentration
0.3-300 nM.
Activity
B-HT 920 is a blocker of 5-HT3 channels1. It is also an agonist of D2 dopamine receptors and α2-adrenoceptors.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Tropanyl-3,5-dimethylbenzoate Cat #: T-135

Size: 25 mg Source: Synthetic MW: 273.4 Purity: >99%
Effective concentration
1 nM - 1 µM.
Activity
Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Tropisetron hydrochloride Cat #: T-125

Size: 10 mg Source: Synthetic MW: 320.76 Purity: >98%
Effective concentration
0.1-10 nM.
Activity
Tropisetron hydrochloride is a potent and selective 5-HT3A channel blocker with Ki ~ 2 nM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

VUF 10166 Cat #: V-115

Size: 5 mg Source: Synthetic MW: 262.74 Purity: >99%
Effective concentration
0.05 nM – 100 nM.
Activity
VUF 10166 is a potent and selective 5-HT3A and B receptor antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Zacopride hydrochloride Cat #: Z-110

Size: 5 mg Source: Synthetic MW: 346.25 Purity: >98%
Effective concentration
0.3-300 nM.
Activity
Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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