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Alpha-Conotoxin TxID

α-Conotoxin TxID, α-CTx TxID

A Potent Antagonist of α3/β4 Neuronal nAChR.

Cat #: STC-110
Alternative Name α-Conotoxin TxID, α-CTx TxID
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Conus textile
    Source Synthetic
    MW: 1489.8 Da
    Purity: >98%
    Form Lyophilized Powder
    Effective concentration 20-500 nM
    Sequence GCCSHPVCSAMSPIC-NH2
    Structure
    Molecular formula C58H91N17O19S5
    Activity Alpha-Conotoxin TxID is a potent α3/β4 nAChR antagonist and α6/α3β4 blocker1.
    References-Activity
    1. Luo, S. et al. (2013) J Med Chem., 56, 9655.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DDW. 
    Centrifuge all products before use (10000 x g, 5 min). Avoid multiple freezing and thawing. 
    Storage of solutions Store at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C.
    Our bioassay
    • Alomone Labs Alpha-Conotoxin TxID inhibits α3/β4 nAChR heterologously expressed in Xenopus oocytes.

      Alomone Labs Alpha-Conotoxin TxID inhibits α3/β4 nAChR heterologously expressed in Xenopus oocytes.
      A. Time course of Alpha-Conotoxin TxID (#STC-110) action on α3/β4 nAChR currents, elicited every 50 sec by a transient application of 20 µM ACh, while membrane potential was held at -80 mV. Application of 50 nM (green) and 500 nM (magenta) Alpha-Conotoxin TxID significantly inhibits the currents.
      B. Superimposed traces of α3/β4 nAChR currents evoked by ACh (arrow) after application of control, 50 nM (green) and 500 nM (magenta) Alpha-Conotoxin TxID (taken from the recording in A.
    References - Scientific background
    1. Luo, S. et al. (2013) J Med Chem., 56, 9655.
    2. Xu, P. et al. (2019) FEBS Open Bio., 9, 1561.
    3. Yu, J. et al. (2018) J Med Chem., 61, 9256.
    4. Qian, J. et al. (2019) Eur J Pharmacol., 865, 172674.
    Scientific background

    α-Conotoxin TxID (a-CTx TxID) is a 15 amino acid peptidyl toxin isolated from the mollusk-hunting cone snail, Conus textile. This toxin belongs to the α-4/6 conotoxin (α-CTx) subfamily, that potently blocks the α3β4 nicotinic acetylcholine receptor (nAChR) subtype with high selectivity. In addition, α-CTx TxID blocks the closely related α6/α3β4 nAChR but exhibits minimal activity towards other nAChR subtypes. α-CTx TxID is the most potent α3β4 nAChR antagonist characterized thus far and has a unique selectivity profile 1.

    Neuronal nAChRs are widely distributed throughout the central and peripheral nervous systems. These receptors play important roles in normal physiology and are involved in many diseases such as epilepsy, pain, addiction, Alzheimer's disease, Parkinson's disease, schizophrenia, as well as breast and lung carcinoma. The α3β4 nAChR is the most prevalent subtype in the brain and is associated with nicotine addiction, neuropathic pain and small cell lung cancer2

    Given the diverse functions of the nAChRs, the a-CTx TxID may be a valuable tool for elucidating the distinct roles of the α3β4 nAChRs in a variety of normal and pathological processes1,3. a-CTx TxID has been used for these purposes and it was recently shown to exhibit anti-tumor activity, which may provide novel strategies for cancer treatment4.

    Target α3/β4 nAChR

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    Last update: 02/03/2021

    α-Conotoxin TxID (#STC-110) is a highly pure, synthetic and biologically active peptide toxin.

    For research purposes only, not for human use
    Shipping and Ordering information