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An Antagonist of Muscular α1/β1/γ/δ nAChR

Cat #: STA-100
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 2544 Da
    Purity: >98% (HPLC)
    Effective concentration 0.5-10 µM.
    Molecular formula C118H174N38O26.
    Activity Azemiopsin blocks the adult form (α1/β1/ε/δ) as well as the fetal form (α1/β1/γ/δ) nAChR1.
    1. Utkin, Y.N. et al. (2012) J. Biol. Chem. 287, 27079.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Azemiopsin inhibits fetal muscle nAChR (α1/β1/γ/δ) heterologously expressed in Xenopus oocytes.
      Alomone Labs Azemiopsin inhibits fetal muscle nAChR (α1/β1/γ/δ) heterologously expressed in Xenopus oocytes.
      Time course of Azemiopsin (#STA-100) action on fetal muscle α1/β1/γ/δ nAChR. Current amplitudes were plotted as a function of time. Membrane potential was held at -60 mV and oocytes were stimulated by exposure to 100 µM acetylcholine every 200 seconds. 1 µM (for 5 min) Azemiopsin was perfused during the period marked by the bar.
    References - Scientific background
    1. Utkin, Y.N. et al. (2012) J. Biol. Chem. 287, 27079.
    Scientific background

    Azemiopsin is a 21 amino acid peptidyl toxin, isolated from the Azemiops feae viper venom1 and is a synthetic version of the peptide. Unlike similar venom isolates, it does not contain cysteine residues1.

    Azemiopsin efficiently competes with α-Bungarotoxin (#B-100) for binding to Torpedo nAChR and with lower efficiency to human α7 nAChR. It dose-dependently blocks ACh-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR and is more potent against the adult form than the fetal form1. The peptide has no effect on GABA(A) receptors or on 5-HT3 receptors1.

    Azemiopsin resembles Waglerin-1 (#STW-001) (a disulfide-containing peptide from the Tropidechis wagleri venom) in its biological activity.

    Target α1/β1/γ/δ nAChR
    Peptide Content: 100%
    Last update: 06/11/2022

    Azemiopsin (#STA-100) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use
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