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Endothall

An Inhibitor of Protein Phosphatase 1 and Protein Phosphatase 2A

Cat #: E-180
Lyophilized Powder yes
Source Synthetic
MW: 186.16
Purity: >98%
Effective concentration 200-500 nM.
Structure
Chemical name 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid.
Molecular formula C8H10O5.
CAS No.: 145-73-3
Activity Endothall is a cantharidin analogue and potently inhibits PP2A (IC50 = 90 nM) with a slight effect on PP1 (IC50 = 5 µM)1.
References-Activity
  1. Li, Y.M. et al. (1993) Biochem. Pharmacol46, 1435.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
References - Scientific background
  1. Li, Y.M. et al. (1993) Biochem. Pharmacol46, 1435.
  2. Herzig, S. and Neumann, J. (2000) Physiol. Rev. 80, 173.
Scientific background

Endothall is a synthetic structural analogue of Cantharidin (#C-170), widely used in agriculture as a pesticide and herbicide for both terrestrial and aquatic weeds1,2.

Endothall was found as a potent inhibitor of spinach leaf Protein Phosphatase 1 and Protein Phosphatase 2A but a less potent inhibitor than Cantharidin for mammalian liver Protein Phosphatase 1 and Protein Phosphatase 2A.

Endothall is a more effective herbicide than Cantharidin possibly due to the expression of various Protein Phosphatases in plant or to permeability differences1,2.

Last update: 02/03/2021

Endothall (#E-180) is a highly pure, synthetic, and biologically active compound.

For research purposes only, not for human use

Applications

Specifications

Scientific Background

Citations

Citations
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