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Cantharidic Acid

A Potent Inhibitor of Protein Phosphatase 1 and Protein Phosphatase 2A

Cat #: C-250
Lyophilized Powder yes
Origin Mylabris phalerata (Chinese blister beetle).
Source Semi-synthetic
MW: 258.18
Purity: >99%
Effective concentration 100 nM - 1 µM.
Chemical name 5’-3’2,3-Dicarboxy-2,3-dimethyl-1,4-epoxycyclohexane, exo-1,6-Dicarboxy-endo-1,6-dimethyl-7-oxabicylco[2,2,1]heptane.
Molecular formula C10H14O5Na2.
CAS No.: 28874-45-5
Activity Cantharidic acid is a potent inhibitor of PP1 and PP2A (IC50 = 50 nM)1,2.
  1. Li, Y.M. and Casida, J.E. (1992) Proc. Natl. Acad. Sci. U.S.A89, 11867.
  2. Li, Y.M. et al. (1993) Biochem. Pharmacol46, 1435.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
References - Scientific background
  1. Li, Y.M. et al. (1993) Biochem. Pharmacol46, 1435.
  2. Hong, S.J. (2000) Br. J. Pharmacol130,1211.
  3. Krautheim, A. et al. (2000) Br. J. Pharmacol. 129, 687.
  4. Laidley, C.W. et al. (1997) J. Pharmacol. Exp. Ther280, 1152.
Scientific background Cantharidic acid is a lipophilic structural analogue of Cantharidin (#C-170), isolated from Mylabris phalerata (Chinese blister beetle)1. Similarly to Cantharidin, Cantharidic acid is a specific inhibitor of serine/threonine protein phosphatases 1 and 2A. Cantharidic acid was found to be 5 to 12 times more potent against the catalytic subunit of protein phosphatase 2A than the catalytic subunit of protein phosphatase 11. Cantharidic acid is widely used to study the role of protein phosphatases in the regulation of various physiological functions2-4.
Last update: 06/11/2022

Cantharidic Acid (#C-250) is a highly pure, semi-synthetic, and biologically active compound.

For research purposes only, not for human use
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