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Etodolac

Etodolic acid, Lodine, Ultradol, Lodine XL
A Selective Activator of TRPA1 Channel
Cat #: E-140
Alternative Name Etodolic acid, Lodine, Ultradol, Lodine XL
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 287.3
    Purity: >98%
    Form Lyophilized powder.
    Effective concentration 1-100 µM.
    Structure
    Chemical name 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid.
    Molecular formula C17H21NO3.
    CAS No.: 41340-25-4.
    PubChem CID 3308
    Activity Etodolac activates TRPA1 channels with an EC50 value of 10 µM1.
    References-Activity
    1. Inoue, N. et al. (2012) Pharmacology 90, 47.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Etodolac activates TRPA1 channels expressed in HEK-293 cells. 
      Alomone Labs Etodolac activates TRPA1 channels expressed in HEK-293 cells. 
      Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements.  Calcium signal was apparent with 50 and 100 µM Etodolac (#E-140).
    References - Scientific background
    1. Tirunagari, S.K. et al. (2009) Cochrane Database Syst. Rev. 8, CD007357.
    2. Pandey, P. et al. (2013) Indian J Pharm. Sci. 75, 406.
    Scientific background

    Etodolac is a racemic acetic acid derivative and nonselective cyclooxygenase (COX) inhibitor that belongs to the class of nonsteroidal anti-inflammatory drugs (NSAID).

    Etodolac has analgesic potential and anti-inflammatory activities and being used in treatment and management of mild to moderate pain. The drug is effective in the treatment of various acute and chronic musculoskeletal conditions, including osteoarthritis of all joints and helps to relieve its symptoms such as inflammation, swelling, stiffness, and joint pain. In addition, Etodolac is being used as a selective activator of TRPA11,2.

    Target TRPA1 channel
    Last update: 22/09/2020

    Etodolac (#E-140) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information