- Deng, M. et al. (2014) Neuropharmacology 79, 657.
- Alomone Labs Huwentoxin-XVI inhibits the current of CaV2.2 channels expressed in Xenopus oocytes.A. Representative time course of Huwentoxin-XVI (#STH-105) inhibition of CaV2.2 (α1B + α2δ1 + β1) channel peak current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage ramp to +60 mV every 10 sec, and inhibited by 7.5 µM Huwentoxin-XVI (green). B. Superimposed traces of CaV2.2 currents after application of control (black) and of 7.5 µM Huwentoxin-XVI (green), taken from the recording in A.
Huwentoxin XVI (HWTX-XVI) is a peptide toxin originally isolated from the Chinese bird spider Selenocosmia huwena venom1.
Huwentoxin-XVI is a specific blocker of N-type (CaV2.2) Ca2+ channels. It has no effect on voltage-gated T-type Ca2+ channels, K+ channels or Na+ channels.
Treatment with this toxin was shown to almost completely block the twitch response of rats in response to low-frequency electrical stimulation and to elicit significant analgesic responses to formalin-induced inflammation pain, In addition it has been shown to have higher reversibility rate than other known Ca2+ channels blockers. These findings suggest that HWTX-XVI could be a novel potential analgesic agent with high potency and low side effects2.
Huwentoxin-XVI (#STH-105) is a highly pure, synthetic, and biologically peptide toxin.