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L-AP4

L-APB; L-(+)-2-Amino-4-phosphonobutyric acid

A Potent and Selective Agonist of Group III mGluRs

Cat #: L-150
Alternative Name L-APB; L-(+)-2-Amino-4-phosphonobutyric acid
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 183.1
    Purity: >97% (HPLC)
    Effective concentration 0.1-100 µM.
    Structure
    Chemical name (2S)-2-amino-4-phosphonobutanoic acid.
    Molecular formula C4H10NO5P.
    CAS No.: 23052-81-5
    PubChem CID 179394
    Activity L-AP4 is a group III mGluR specific agonist. Reversibly depresses basal synaptic transmission in rat hippocampal slices (IC50 = 3 µM)1.
    References-Activity
    1. Bushell, T.J. et al. (1996) Br. J. Pharmacol. 117, 1457.
    2. Thomsen, C. (1997) Gen. Pharmacol. 29, 151.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs L-AP4 inhibits specific binding of L-Glutamic acid to rat brain glutamate receptors.
      Alomone Labs L-AP4 inhibits specific binding of L-Glutamic acid to rat brain glutamate receptors.
      Percent inhibition of specific binding of 3.75 nM [3H]-L-Glutamic acid to membranes from whole rat brain (except cerebellum) was plotted against concentrations of L-AP4 (#L-150), (green circles) and of L-Glutamic acid (assay standard, black squares) and used to calculate IC50 and Ki values for L-AP4 (IC50 ≈ 4.49 µM, and Ki ≈ 4.43 µM).
    References - Scientific background
    1. Bushell, T.J. et al. (1996) Br. J. Pharmacol. 117, 1457.
    2. Thomsen, C. (1997) Gen. Pharmacol. 29, 151.
    Scientific background

    L-AP4 is a synthetic, potent and selective agonist of group III metabotropic glutamate receptors (mGluR4 and mGluR6 through mGluR8). L-AP4 also depresses basal synaptic transmission in rat hippocampal slices with an IC50 of 3 µM in a dose dependent manner. Maximum depression of 74% is obtained at a concentration of 100 µM L-AP4. A concentration of 10 µM L-AP4 induces a depression of 59% and when the mGluR antagonist MCCG is added it shows little or no effect. In contrary, the mGluR antagonists MPPG and MTPG are effective L-AP4 antagonists1.

    L-AP4-sensitive neuronal glutamatergic pathways include synapses of the mossy-fiber/ CA3 projection synapses of pyramidal cell projecting from the lateral olfactory tract to the pyriform cortex and synaptic contacts in the basolateral amygdala. It has also been suggested that L-AP4 sensitive receptors are important for memory and learning and might be implicated in the pathogenesis of Alzheimer’s disease2.

    Target mGluR4, 6, 7, 8
    Lyophilized Powder
    Last update: 06/11/2022

    L-AP4 (#L-150) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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