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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the mGluR1 Antagonist Explorer Kit (#EK-250). The Explorer Kit contains mGluR1 antagonists, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
A-794278 | A-435 | 1 x 5 mg |
A-850002 | A-390 | 1 x 5 mg |
CFMTI | C-365 | 1 x 5 mg |
CPCCOEt | C-370 | 1 x 5 mg |
DM-PPP | D-255 | 1 x 5 mg |
EM-TBPC | E-165 | 1 x 5 mg |
FPTQ | F-185 | 1 x 5 mg |
FTIDC | F-190 | 1 x 5 mg |
JNJ 16259685 | J-110 | 1 x 5 mg |
LY 456236 hydrochloride | L-235 | 1 x 5 mg |
LY456066 | L-240 | 1 x 5 mg |
MK-5435 | M-265 | 1 x 5 mg |
NPS 2390 | N-340 | 1 x 5 mg |
Scientific Background
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mGluR1 is predominantly expressed in nervous tissue although expression in several non-neural cell types has also been described. In the brain it is highly expressed in the hippocampus, cerebellum, olfactory bulb and thalamus.
The mGluR1 receptor is involved in several physiological processes such as neuronal development, induction of long-term potentiation (LTP) and depression (LTD) as well as in pathological disorders such as brain trauma, chronic pain, Parkinson’s and Huntington’s disease.
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- Dhami, G.K. and Ferguson, S.S. (2006) Pharmacol. Ther. 111, 260.
- Ferraguti, F. and Shigemoto, R. (2006) Cell Tissue Res. 326, 483.
- Kew, J.N. and Kemp, J.A. (2005) Psychopharmacol. (Berl.) 179, 4.
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