- Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
- Bioassay Tested Bioassay Tested
This antibody has undergone quality control and has been approved by our professional team.
- Shipped at Room Temp. Shipped at Room Temp.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
Alomone Labs is pleased to offer the Muscarinic Receptor Antagonist Explorer Kit (#EK-206). The Explorer Kit contains muscarinic receptor antagonists, ideal for screening purposes.
The action of the neurotransmitter acetylcholine (ACh) is mediated through two types of receptors; ionotrophic nicotinic receptors and metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-transmembrane G-protein coupled receptors. Five subtypes of muscarinic receptors have been cloned and named m1-m5.1-2
The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues.1-2
Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control.1 They also participate in learning and memory processing.3-4 The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors were also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves.5-6
- Ferreira, A.R. et al. (2003) Pharmacol. Biochem. Behav. 74, 411.
- Forsythe, S.M. et al. (2002) Am. J. Respir. Cell. Mol. Biol. 26, 298.
- Felder, C.C. et al. (2000) J. Med. Chem. 43, 4333.
- Wang, J. et al. (2000) Am. J. Physiol. 279, G1059.
- Van der Zee, E.A. et al. (1999) Prog. Neurol. 58, 409.
- Levey, A.I. et al. (1991) J. Neurosci. 11, 3218.
- Anti-M1 Muscarinic Receptor Antibody (#AMR-001)
- Anti-M2 Muscarinic Receptor Antibody (#AMR-002)
- Anti-M3 Muscarinic Receptor Antibody (#AMR-006)
- Anti-M4 Muscarinic Receptor Antibody (#AMR-004)
- Anti-M5 Muscarinic Receptor (extracellular) Antibody (#AMR-005)
- Muscarinic Receptor Antibody Explorer Kit (#AK-206)