Opioid Receptor Antibody Explorer Kit

A Screening Package of Opioid Receptor Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-520
Sizes: 8 Vials
Last update: 24/04/2019

Alomone Labs is pleased to offer the Opioid Receptor Antibody Explorer Kit (#AK-520). The Explorer Kit contains opioid receptor antibodies, ideal for screening purposes.

For research purposes only, not for human use
Scientific Background
Scientific Background

Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors. Three "classic" types of opioid receptors have been identified: mu (µ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor.1 Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic µ, δ, and κ receptors.2

The opioid receptors belong to the G protein-coupled receptor (GPCR) superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important for binding G proteins.1

All three classic opioid receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the µ-opioid receptor, whereas µ-, δ-, and κ-receptors participate in the control of pain at the spinal level.3 The opioid receptors also mediate the mood-altering properties of opioids.4 Cross-talk between µ- and δ- opioid receptors was demonstrated when subeffective doses of d-opioid receptors agonists modulated m-mediated analgesia.5

  1. Pan, L. et al. (2005) Neuroscience 133, 209.
  2. http://www.iuphar-db.org/DATABASE/FamilyIntroductionForward?familyId=50.
  3. Matthes, H.W. et al. (1998) J. Neurosci. 18, 7285.
  4. Di Chiara, G. and North, R.A. (1992) Trends Pharmacol. Sci. 13, 185.
  5. Vaught, J.L. et al. (1982) Life Sci. 30, 1443.
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