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Tropanyl-3,5-dimethylbenzoate

An Antagonist of 5-HT3 Receptors

Cat #: T-135
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 273.4
    Purity: >99%
    Effective concentration 1 nM - 1 µM.
    Structure
    Chemical name (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dimethylbenzoate.
    Molecular formula C17H23NO2.
    CAS No.: 85181-40-4
    PubChem CID 2837530
    Activity Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist1.
    References-Activity
    1. Yang, N. et al. (2010) Br. J. Pharmacol. 159, 1623.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Tropanyl-3,5-dimethylbenzoate citrate blocks 5-HT3A receptors expressed in HEK 293T cells. 
      Alomone Labs Tropanyl-3,5-dimethylbenzoate citrate blocks 5-HT3A receptors expressed in HEK 293T cells. 
      5-HT3A receptor currents were elicited with 10 µM 5-HT, delivered every 3 minutes. Tropanyl-3,5-dimethylbenzoate (#T-135) was applied 30 seconds before stimulation at 1, 10 and 50 µM as indicated and completely inhibited the 5-HT induced current in a dose dependent and reversible manner.
    References - Scientific background
    1. Hannon, J. et al. (2008) Behav. Brain Res. 195, 198.
    2. Yang, N. et al. (2008) Eur. J. Pharmacol. 584, 137.
    Scientific background

    Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.

    Tropanyl-3,5-dimethylbenzoate is a synthetic, potent and selective antagonist of the 5-HT3 receptor. Tropanyl-3,5-dimethylbenzoate has an effective concentration of 1 nM – 1 μM. Interestingly, in rat mucosa and submucosa preparations Tropanyl causes an increase of 5-HT induced Δ/sc (change in short circuit current) and causes a decline of Δ/sc in rat intact colon suggesting a double role for 5-HT3 receptors in this tissue2.

    Target 5-HT3 receptors
    Last update: 24/01/2021

    Tropanyl-3,5-dimethylbenzoate (#T-135) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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