This product has recently been released.
This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Kozek, K.A. et al. (2018) ACS Chem. Neurosci. doi: 10.1021/acschemneuro.8b00287.
Alomone Labs VU0529331 activates homomeric GIRK2 (Kir3.2) channels expressed in Xenopus oocytes.Representative time course of GIRK2 (Kir3.2) current, measured in continuously applied high K+-containing bath solution (top dotted line), and activated by 30 µM VU0529331 (#V-155), as indicated, at a holding potential of -80 mV.
VU0529331 is an activator of the homomeric and of non-GIRK1-containing GIRK channels. The activity of the compound is much stronger on non-GIRK1/X channels. VU0529331 does not change the potassium selectivity or rectification of GIRK channels1. VU0529331 activates GIRK2 and GIRK4 homomeric channels expressed in HEK293 cells and demonstrates EC50 values of 5.1 and 22.3 µM respectively1.
The GIRK family, also known as the Kir3 family, is part of the larger inwardly rectifying potassium channel (Kir) family. GIRK channels play an important role in the regulation of cellular excitability. GIRK channels are heterotetrameric or homotetrameric combinations of the GIRK1−GIRK4 subunits. GIRK channels are associated with a variety of neurological disorders and alcohol and drug addiction1,2.
VU0529331 (#V-155) is a highly pure, synthetic, and biologically active compound.