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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Antigen Incl. Control Antigen IncludedThis antibody is shipped with its antigen FREE of charge!
Alomone Labs is pleased to offer the Kir Channel Antibody Explorer Kit (#AK-200). This Explorer Kit includes antibodies targeted against Kir channels along with their respective peptide control antigen (where applicable). An ideal tool for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-KCNJ1 (Kir1.1) Antibody | APC-001 | 1 x 50 µl |
Anti-Kir2.1/KCNJ2 Antibody | APC-026 | 1 x 50 µl |
Anti-Kir2.2 (KCNJ12) Antibody | APC-042 | 1 x 50 µl |
Anti-Kir2.3 (KCNJ4) Antibody | APC-032 | 1 x 50 µl |
Anti-GIRK1 (Kir3.1) Antibody | APC-005 | 1 x 50 µl |
Mouse Anti-GIRK1 (Kir3.1) (extracellular) Antibody | ALM-031 | 1 x 25 µg |
Anti-GIRK2 (Kir3.2) Antibody | APC-006 | 1 x 50 µl |
Anti-GIRK3 (Kir3.3) Antibody | APC-038 | 1 x 50 µl |
Anti-KCNJ5 (Kir3.4) Antibody | APC-027 | 1 x 50 µl |
Anti-Kir4.1 (KCNJ10) Antibody | APC-035 | 1 x 50 µl |
Guinea pig Anti-Kir4.1 (KCNJ10) Antibody | AGP-012 | 1 x 50 µl |
Anti-Kir4.1 (KCNJ10) (extracellular) Antibody | APC-165 | 1 x 50 µl |
Anti-KCNJ15 (Kir4.2) Antibody | APC-058 | 1 x 50 µl |
Anti-Kir5.1 Antibody | APC-123 | 1 x 50 µl |
Anti-Kir6.1 (KCNJ8) Antibody | APC-105 | 1 x 50 µl |
Anti-Kir6.2 Antibody | APC-020 | 1 x 50 µl |
Guinea pig Anti-Kir6.2 Antibody | AGP-067 | 1 x 50 µl |
Anti-Kir7.1 (extracellular) Antibody | APC-125 | 1 x 50 µl |
Scientific Background
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Kir1.1 (ROMK1) was the first member of the family of inward rectifying K+ channels to be cloned1. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunits that can assembly as either homo- or heterotetramers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis2.
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- Ho, K. et al. (1993) Nature 362, 31.
- Wang, W.H. (2006) Am. J. Physiol. Renal Physiol. 290, F14.
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