Kir Channel Antibody Explorer Kit

A Screening Package of Kir Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-200
Sizes: 35 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the Kir Channel Antibody Explorer Kit (#AK-200). This Explorer Kit includes antibodies targeted against Kir channels along with their respective peptide control antigen (where applicable). An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-Kir1.1 (ROMK1) Antibody
APC-001 1 x 50 µl
Anti-Kir2.1 (KCNJ2) Antibody
APC-026 1 x 50 µl
Anti-Kir2.2 Antibody
APC-042 1 x 50 µl
Anti-Kir2.3 Antibody
APC-032 1 x 50 µl
Anti-GIRK1 (Kir3.1) Antibody
APC-005 1 x 50 µl
Mouse Anti-GIRK1 (Kir3.1) (extracellular) Antibody
ALM-031 1 x 25 µg
Anti-GIRK2 (Kir3.2) Antibody
APC-006 1 x 50 µl
Anti-GIRK3 (Kir3.3) Antibody
APC-038 1 x 50 µl
Anti-Kir3.4 (GIRK4) Antibody
APC-027 1 x 50 µl
Anti-Kir4.1 (KCNJ10) Antibody
APC-035 1 x 50 µl
Guinea pig Anti-Kir4.1 (KCNJ10) Antibody
AGP-012 1 x 50 µl
Anti-Kir4.1 (KCNJ10) (extracellular) Antibody
APC-165 1 x 50 µl
Anti-Kir4.2 Antibody
APC-058 1 x 50 µl
Anti-Kir5.1 Antibody
APC-123 1 x 50 µl
Anti-Kir6.1 Antibody
APC-105 1 x 50 µl
Anti-Kir6.2 Antibody
APC-020 1 x 50 µl
Guinea pig Anti-Kir6.2 Antibody
AGP-067 1 x 50 µl
Anti-Kir7.1 (extracellular) Antibody
APC-125 1 x 50 µl
Note A mouse monoclonal antibody (#ALM-031) and guinea pig polyclonal antibodies (#AGP-012 & #AGP-067) are included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

Kir1.1 (ROMK1) was the first member of the family of inward rectifying Kchannels to be cloned1. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.

The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunits that can assembly as either homo- or heterotetramers.

Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis2.

References
  1. Ho, K. et al. (1993) Nature 362, 31.
  2. Wang, W.H. (2006) Am. J. Physiol. Renal Physiol. 290, F14.
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