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Home › Products › Research Areas › Membrane Proteins and Pain › Ion Channels in Pain › Activators

Certificate of Analysis

WS 12
In wishlist

(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
An Activator of TRPM8 Channel
    Cat #: W-105
    Alternative Name (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
  • Lyophilized Powder
    Lyophilized Powder

    This product is freeze dried. All water molecules have been removed.

  • Bioassay Tested
    Bioassay Tested

    Every lot is tried & tested in a relevant biological assay.
    Our Bioassay

    • Source Synthetic
    MW: 289.41
    Purity: >99%
    Effective concentration 1 nM – 10 µM.
    Structure
    • WS 12
    Chemical name (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide.
    Molecular formula C18H27NO2.
    CAS No.: 68489-09-8.
    PubChem CID 11266244
    Activity WS 12 is a TRPM8 channel activator (EC50 = 193 nM)1.
    References-Activity
    1. Bodding, M. et al. (2007) Cell Calcium 42, 618.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 75 mM in Ethanol. Centrifuge all products before use (10000 x g 5 min).
    Storage of solutions Up to three months at -20°C.
    Our bioassay
    • WS 12
      Alomone Labs WS 12 activates TRPM8 channels expressed in HEK-293 cells.
      Dose response curve for the activation of human TRPM8 by rising concentrations of WS 12 (#W-105), showing activity at low nanomolar range. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+ were detected as changes in 485 nm/525 nm fluorescence following agonist application.
    Scientific background

    The carboxamide WS 12 is a synthetic selective TRPM8 channel agonist1.

    TRPM8 is a Ca2+-permeable channel, a member of the ‘long' or melastatin (M) group of TRP proteins and is activated by temperatures or by cooling compounds such as icilin, menthol and eucalyptol. The TRPM8 gene is expressed and is up-regulated in prostate cancer and other malignancies. It is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons1-3.

    Target TRPM8 channel
    Lyophilized Powder
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    Last update: 24/01/2020
    For research purposes only, not for human use

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