TRPM Channel Antibody Explorer Kit

A Screening Package of TRPM Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-210
Sizes: 16 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the TRPM Channel Antibody Explorer Kit (#AK-210). This Explorer Kit includes antibodies directed against TRPM channels.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-Human TRPM1 Antibody
ACC-041 1 x 50 µl
Anti-TRPM2 Antibody
ACC-043 1 x 50 µl
Anti-TRPM3 (extracellular) Antibody
ACC-050 1 x 50 µl
Anti-TRPM4 Antibody
ACC-044 1 x 50 µl
Anti-TRPM5 Antibody
ACC-045 1 x 50 µl
Anti-TRPM6 (extracellular) Antibody
ACC-046 1 x 50 µl
Anti-TRPM7 Antibody
ACC-047 1 x 50 µl
Anti-TRPM8 (extracellular) Antibody
ACC-049 1 x 50 µl
Scientific Background
Scientific Background

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the six TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3

According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC (canonical), TRPV (vanilloid) and TRPM (melastatin). To date, three extra subfamilies are also considered to belong to the TRP family; the TRPA, TRPML, and the TRPP.1-4

The TRPM subfamily consists of eight members, TRPM1 to TRPM8, which also can be further subdivided into four subgroups based on their sequence homology: (1)TRPM1 and TRPM3 (2) TRPM6 and TRPM7 (3) TRPM4 and TRPM5 (4) TRPM2 and TRPM8.5

References
  1. Montell, C. et al. (2002) Mol. Cell9, 229.
  2. Clapham, D.E. (2003) Nature 426, 517.
  3. Moran, M.M. et al. (2004) Curr.Opin.Neurobiol14, 362.
  4. Clapham, D.E. et al. (2003) Pharmacol. Rev55, 591.
  5. Harteneck, C. (2005) Naunyn Schmiedebergs Arch Pharmacol371, 307.
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