Lyophilized Powder This product is freeze dried. All water molecules have been removed.
Antigen Incl. This antibody is shipped with its antigen FREE of charge!
Alomone Labs is pleased to offer the TRPM Channel Antibody Explorer Kit (#AK-210). This Explorer Kit includes antibodies directed against TRPM channels.
| Product Name | Cat # | Size |
|---|---|---|
Anti-Human TRPM1 Antibody | ACC-041 | 1 x 50 µl |
Anti-TRPM2 Antibody | ACC-043 | 1 x 50 µl |
Anti-TRPM3 (extracellular) Antibody | ACC-050 | 1 x 50 µl |
Anti-TRPM4 Antibody | ACC-044 | 1 x 50 µl |
Anti-TRPM5 Antibody | ACC-045 | 1 x 50 µl |
Anti-TRPM6 (extracellular) Antibody | ACC-046 | 1 x 50 µl |
Anti-TRPM7 Antibody | ACC-047 | 1 x 50 µl |
Anti-TRPM8 (extracellular) Antibody | ACC-049 | 1 x 50 µl |
TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the six TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3
According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC (canonical), TRPV (vanilloid) and TRPM (melastatin). To date, three extra subfamilies are also considered to belong to the TRP family; the TRPA, TRPML, and the TRPP.1-4
The TRPM subfamily consists of eight members, TRPM1 to TRPM8, which also can be further subdivided into four subgroups based on their sequence homology: (1)TRPM1 and TRPM3 (2) TRPM6 and TRPM7 (3) TRPM4 and TRPM5 (4) TRPM2 and TRPM8.5
